Mixing powders into liquids efficiently is crucial to productivity in pharmaceutical and biopharmaceutical manufacturing. In some operations, high shear is beneficial, and the resulting heat causes no problems. However, for operations where low shear and high product integrity are required, traditional technologies pose a risk to the quality of the final product.
For these applications, ILC Dover has developed a patented venturi system that nullifies shear and excessive heat, while ensuring complete powder mixing. To prove efficacy, ILC Dover partnered with a large manufacturer to test the system in the manufacturer’s plant.
Here we review the technology, operation and testing protocols, and present the results that demonstrate the venturi system’s efficacy for low-shear, low-heat applications.