Las Vegas, NV /PRNewswire/ — With the realization that half of the people experiencing a sudden mortal heart attack were taking aspirin on the day of their demise, researchers have begun to search for a more reliable alternative, and they may have found it in a red wine molecule called resveratrol (rez-vair-ah-trawl).
Researchers at the University of Connecticut induced heart attacks in animals and found resveratrol significantly reduces damage to heart muscle. Scarring and fibrosis were limited and the animals survived an otherwise mortal event.
Dipak Das, Ph.D., Sc.D., MD (hon), professor and director of the Cardiovascular Research Center at the University of Connecticut, School of Medicine in Farmington, Connecticut, says resveratrol provokes a "pre-conditioning effect" whereby antioxidant defenses in the heart are switched on prior to a heart attack, therefore limiting damage to heart muscle should such an event occur.
Das says: "Resveratrol likely fulfills the definition of a pharmacological preconditioning compound and gives hope for the therapeutic promise of alternative medicine."1 Das goes on to say resveratrol's preconditioning effect is "the best yet devised method of cardioprotection."2
The dosage of resveratrol is critical in producing the pre-conditioning effect – Dr. Das found the human equivalent dosage of 175-350 milligrams reduced damage to the heart during a heart attack, while ten times greater dose (1750-3500 mg) increased the area of damaged cardiac tissue.
A branded resveratrol pill, Longevinex® (www.longevinex.com ) , was found to afford the same level of protection at a much lower dose – 100 milligrams of resveratrol, which may be due to its micronized, micronencapsulated delivery system and combination with other antioxidants (quercetin, rice bran, vitamin D and ferulic acid).
Since resveratrol also thins the blood and inhibits clots that form in coronary arteries in a similar fashion to aspirin, and exhibits other beneficial properties, such as anti-adhesion factors that inhibit plaque from sticking to artery walls, it may be superior to aspirin.
Wine consumption is also believed to afford similar protection for the heart. The red wine-drinking French exhibit a coronary heart disease mortality rate that is extremely low – 90 per 100,000 versus 240 per 100,000 in North America.
The amount of resveratrol in 3 to 5 glasses of red wine is only about 3-5 milligrams, but the heart protective effect is believed to be produced by the total polyphenolic molecules in a glass of dark, aged red wine, ~60 milligrams per 5-ounce glass. The optimal health benefit derived from red wine is achieved at a consumption level of 3-5 glasses, which would be considerably more expensive than a resveratrol pill, and certainly pose the problem of inebriation.
The heart preconditioning effect of resveratrol is produced by the natural release of adenosine, which is actually employed as a drug to restore natural heart rhythm.
An online documentary film, featuring an interview with Dr. Das, is available for viewing at http://www.resveratrolcentral.com/aspirinresveratrol/.
Background Information: resveratrol/ Longevinex® pill as alternative to aspirin
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2. Das DK, Maulik N, Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Mol Interv. 2006 Feb; 6(1):36-47.
3. Wald NJ, Law MR, A strategy to reduce cardiovascular disease by more than 80%. BMJ 2003 Jun 28; 326(7404):1419.
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10. Blardi P, De Lalla A, Volpi L, Di Perri T, Stimulation of endogenous adenosine release by oral administration of quercetin and resveratrol in man. Drugs Exp Clin Res. 1999; 25(2-3):105-10.
11. Bradamante S, Piccinini F, Barenghi L, et al, Does resveratrol induce pharmacological preconditioning? Int J Tissue React. 2000; 22(1):1-4.
12. Das S, Das DK, Resveratrol: a therapeutic promise for cardiovascular diseases. Recent Pat Cardiovasc Drug Discov. 2007 Jun; 2(2):133-8.
13. Das DK, Maulik N, Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Mol Interv. 2006 Feb; 6(1):36-47.