Scaling Difficult Chemistry Without Site Transfers: Inside Curia Origgio

Scale-up is rarely a matter of moving the same reaction into a larger vessel, and the gap widens for cryogenic, organometallic, high-pressure and transition-metal-catalyzed steps. This look at a GMP site in Origgio, Italy centers on a practical evaluation question for CMC and external-manufacturing teams: can a proposed site run the hardest step in the route at the scale the program will eventually need? It covers the site's reactor range, its volume of low-temperature work, its hydrogenation capacity and catalyst handling, and what staying at one site does and does not change for development, validation and change control. It also addresses site history and inspection record.

Explore the site profile to see how the specifics hold up against your own route requirements.