Seal Inspection Technologies for Tablets & Capsules Packaging

Source: PTI Packaging and Inspection Systems
Blister Package

Non-destructive package testing of multi-cavity blisters – completely tool-less for different blister formats.

Blister packaging is one of the most practical and convenient packaging formats for tablets and capsules. Blister packaging is specifically used for tablets and capsules to pack them in a convenient and controlled way for easy patient use.

Blister packagings are designed for long and temper proof shelf life by eliminating moisture ingress and contamination. In today’s drug delivery systems where certain drugs are extremely sensitive to moisture and Oxygen, it is critical to ensure the package integrity of blister packs to ensure that product quality is not compromised.

Vacuum decay is a non-destructive container closure integrity testing method for blister packaging. PTI offers two technologies for integrity testing of multi-cavity blister packaging.

The VeriPac Universal Blister Verification (UBV) Leak Detection System is a deterministic non-destructive technology designed specifically for multi-cavity blister packs. The VeriPac UBV utilizes volumetric imaging under vacuum to detect the presence and location of leaks.

It’s a rapid test requiring no changeover or sample preparation. Operators simply place the blister pack on the inspection station and press the START button. Within seconds, the operator sees a definitive pass/fail result, along with a quantitative measurement reading. The location of the defective cavity is presented to the operator with an image of the tested package. The small footprint kiosk design is ideal for positioning next to any production line. The clean and simple test approach makes it cleanroom compatible. The intuitive and simple method makes it a practical solution giving rapid feedback to production line operators.

The UBV technology is unique in that it can provide rapid detection of defects as small as 10 microns with a fast test time, averaging 10-30 seconds depending on blister cavity volume. The test system requires no tools or test parameter changes for different blister formats. This technology is particularly advantageous for small to tiny blister cavities that are notoriously difficult to detect with a standard vacuum system due to the very low headspace.


  • Non-destructive technology
  • Accurate and repeatable results
  • Pass/fail results backed by quantitative test data
  • Completely tool-less with no changeover to test different blister formats
  • Identifies which cavity is defective
  • Eliminates destructive, subjective testing methods

Inspection Criteria

  • Leak detection and seal integrity testing of entire package
  • Test sensitivity down to 10 microns