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Set-Up And Validation Of A Clean In Place (CIP) System For A Coating Pan

Source: IMA S.p.A.

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•White Paper: Set-Up And Validation Of A Clean In Place (CIP) System For A Coating Pan

The accurate cleaning of manufacturing equipment and facilities has always been a mandatory requirement for the pharmaceutical industry. Today, it is becoming more and more stringent because of many different reasons, including the introduction of more potent active pharmaceutical ingredients, as well as the need to comply with increasingly demanding regulatory guidelines. In this respect, the validation of cleaning procedures is a crucial activity to avoid cross-contamination, not only for manufacturing sites, but also for the sampling-filling suite in research and development. This activity implies the assessment of the efficiency of the cleaning steps for eliminating ingredients and detergent residues.

Equipment contamination stems from the materials used in the production, as well as from the environment and the people. In order to reduce manual intervention, many industries are developing manufacturing machines equipped with clean in place (CIP) features.

In this study, the clean in place of a coating pan was examined as a paramount example of difficult to clean pharmaceutical equipment. In particular, the compliance of the CIP procedure was the most updated guidelines was verified.

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•White Paper: Set-Up And Validation Of A Clean In Place (CIP) System For A Coating Pan