Article: High Pressure Homogenization of Inhalation Products

Treatment of respiratory diseases like asthma and chronic obstructive pulmonary disease is advantages via inhalation route compared to the oral route since the active substances are available directly.

Effective therapies directed against asthma have advanced since 1956 when the first pressurized metered dose inhaler was developed. The target for these anti-asthma medications is the smooth muscle cells concentrated in the pulmonary airways. Delivery of drugs directly to the lungs is an effective and relatively safe means of both local and systemic treatment of a variety of medical conditions. Medication delivery may be inefficient if particles aggregate in the inhaler itself, if they are filtered by the throat and mouth, and if mucociliary clearance processes remove them.