Solutions For Liquisolid And Lipid-based Formulations In Pharmaceuticals

SYLOID® XDP silicas are meso-porous, amorphous, silica gel excipients with a unique morphology that create an excellent solid porous carrier for pharmaceutical formulations. The combined adsorption capacity, porosity, particle size, and density provides a tool to create formulations which can expedite manufacturing and improve efficacy of the final dosage form.

Lipids are increasingly being used in formulations today as drug solubilizers, adsorption enhancers and vehicles for lipid-based drug delivery, in order to increase the oral bioavailability of poorly soluble drugs. While oily actives continue to be discovered, the main challenge in oil-based formulations is converting oily solutions and liquid formulations into compressible solid or semi-solid formulations.

SYLOID® XDP silicas has been specifically designed for converting lipids, oily drugs, and drugs in oil solutions into free flowing powders. They can be effective as adsorbents in techniques such as solid dispersion, semi-solids and in lipid-based technologies such as selfemulsifying drug delivery systems (SEDDS).