Solving Flow and Caking Challenges With Silica Pharmaceutical Excipients

For the proper handling of active ingredients or excipients in powder form, good flow properties are very important. Clumpy or poor flowing powders are difficult to transport and dose. Homogeneous mixing with active pharmaceutical ingredients (APIs) and other ingredients is compromised when caking, sticking (to walls), or electrostatic conditions occur.

The addition of small amounts (0.2-2%) of SYLOID® FP silica can improve flow properties of formulations. The controlled porous morphology of SYLOID® FP silica can create unique interactions, charges, and capillary forces resulting in improved free-flow, glidants, and anti-caking behaviors.