Brochure | September 24, 2018

Spray-Dried Dispersion Technology

Source: Capsugel, a Lonza Company

Many promising drug candidates have low aqueous solubility, and require enabling technologies and formulations to enhance oral bioavailability. At Lonza, we know from experience that innovative thinking and flexible approaches are required, along with an array of technologies with which to optimally meet the specific compound characteristics and target product profile. Amorphous solid dispersion using spray-dried dispersions (SDD) is a proven and highly flexible technology approach to improve bioavailability.

A flexible platform

Pioneered by Bend Research, the SDD platform incorporates compositions, processes and dosage forms designed and proven to meet performance, stability and manufacturability requirements for a diverse range of compounds. With our integrated product development approach Lonza can manufacture SDD formulations for all stages of development from preclinical and first-in-human to late-stage development and commercial production. Drug product intermediates based on SDD technology can be formulated into capsules, tablets and other solid dosage forms.

A streamlined formulation process

Our approach provides rapid and reliable advancement of low-solubility compounds.