Application Note

Sterility Testing Of Products With Antimicrobial Properties


Certain medications contain ingredients like antibiotics and preservatives that can hinder the growth and viability of microbes. This poses a challenge during sterility testing, where it's crucial to remove these inhibitory effects. Otherwise, any microorganisms present in the sample might be missed, leading to a false negative test result.

To mitigate these effects, it is essential to utilize specialized equipment such as the Steridilutor® NEO system and Steritest® NEO devices. These systems play a crucial role in effective testing by adhering to three golden rules: maximizing solubility through adequate dissolution or dilution of the test product, minimizing contact time with the membrane to prevent adsorption, and optimizing rinsing to thoroughly remove any residues. Adhering to these guidelines ensures the reliability of sterility tests for products containing antimicrobial properties.

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