Supel™ BioSPME 96-Pin Devices For Fast And Simple Plasma Protein Binding Studies

Protein binding properties of drugs are important to measure to understand the amount of free drug available in the blood. Historical methods to measure protein binding include equilibration of spiked plasma with drugfree buffer across a membrane, preventing the transfer of larger protein molecules into the buffer. This is an equilibrium dialysis method. Rapid equilibrium dialysis methods further reduce the equilibration time from the traditional 24 hours to 4 hours using specifically designed devices.

Based on solid phase microextraction technology, the Supel™ BioSPME 96-Pin Devices are 3x faster than rapid equilibrium dialysis workflows at similar levels of data accuracy and precision. They remove all phospholipids, deliver reproducible results across batches and each 96-sample device, and allow both manual and automated workflows.