Product/Service

Sustained-Release Injectable Products

Source: Interpharm Press, Inc.
In addition to providing invaluable information, this book offers a critical comparison between delivery systems used in marketed drug products and those in development for sustained-release applications.
Edited by Judy Senior and Michael Radomsky

In addition to providing invaluable information, this book offers a critical comparison between delivery systems used in marketed drug products and those in development for sustained-release applications. It examines administration via the subcutaneous or intramuscular routes, local administration to body compartments such as the eye, joints, and tissues, and administration to the intraspinal or epidural regions. Discussions of the various systems/formulations available for sustained-release injectable drug delivery systems focus on the following concerns in pharmaceutical development: PK of drug release, long-term stability/shelf life concerns, toxicological aspects, product clinical effectiveness, manufacturability/GMP/scale-up, regulatory issues, setting product specifications, and analytical methods development challenges.

Special Features:

  • Wide range of sustained-injectable product types are included with the merits of synthetic and natural materials, all collected in this volume
  • Specific drug delivery system insights from 28 pharmaceutical development professionals
  • Solutions to on-the-job problems, including details about regulatory, toxicology, and technology transfer
Chapters include:
  • Rationale for Sustained-Release Injectable Products, Judy Senior
  • Product Development and Principles of Sustained-Release Injected Formulations, Michael Radomsky
  • Commercial Sustained-Release Injectable Formulations by Encapsulation, Mantripragada Sankaram
  • Insoluble Salt Forms and Drug Complexes, Judy Senior
  • Non-aqueous Solutions and Suspensions, Sudaxshina Murdan and A.T. Florence
  • Emulsions for Sustained Drug Delivery, Maninder Hora & Stephen Tuck
  • Liposomes, C. Oussoren, G. Storm, J. Senior & D. Crommelin
  • Synthetic Polymers for Nanosphere and Microsphere Products, M. L. Radomsky, L. S. Liu & T. Iwamoto
  • Nano/Microspheres from Natural Polymers, L. S. Liu & J. Kost
  • In Situ Gelling Formulations, Art Tipton & Dick Dunn
  • Guidelines for Selection of Sustained-Release Technology, Praveen Tyle & Leo Pavliv
  • Veterinary Sustained-Release Parenteral Products, J.C. Lee & M. Putnam
  • Applications in Vaccines and Gene Delivery, Maninder Hora & R. Radhakrishnan
  • Microspheres for Proteins and Peptides: Applications & Opportunities, Paul A. Burke & Scott D. Putney
  • Toxicology and Biocompatibilty Evaluation of Microsphere and Liposome Sustained-Release Drug Delivery Systems, M. Gary, I. Riley & S. Putney
  • Scale-up and Technology Transfer, Kunio Kawamura
  • Quality Control Methods and Specifications, Johanna Lang
  • Regulatory Perspectives and the Product Approval Process, Natalie McClure.
Who Should Use This Book
Pharmaceutical industry and formulation scientists, preformulation and analytical methods professionals, academic pharmacists and pharmacologists will all find this book to be an excellent guide and reference as will all scientists involved in the drug development process related to injectable sustained release drug delivery.
Hardcover, 552 pages

Interpharm Press, Inc., 15 Inverness Way E., Englewood, CO 80112-5776. Tel: 303-662-9101; Fax: 303-754-3953.