Application Note

Swifter, Safer DAC Column Turnover

By Liam Takahashi, Project Engineer, Asahi Kasei Bioprocess America

Swifter Safer DAC Column Turnover

As a means for separating mixtures, liquid chromatography is a tried-and-true – yet very versatile – process that has been relied upon for more than a century. A chromatography

column, such as a solid stainless-steel DAC (Dynamic Axial Compression) column, is an excellent choice to perform such a task. These columns offer the ability to pack any bed height required with a variety of different media types and sizes. The design of these columns allows for a quick, easy and homogeneous packed bed as well as an even distribution for plug flow of liquid to achieve better peak resolution.

One of the trade-offs that comes with using a robust DAC column is the amount of time required for maintenance and turnover between different packs. With this complexity in mind, Asahi Kasei Bioprocess America set out to design an easy-to-implement system that would increase both efficiency and safety during the turnover process. That system is the DAC ERGO column.

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