T3P – A Green Solution For Peptide Coupling And Water Removal Reactions

Here, Dr. Peter Talbiersky, Director of Fine Chemicals at Curia Global, Inc., explores Curia’s T3P® (propanephosphonic acid anhydride), a highly effective green reagent for condensation reactions that has gained widespread adoption across the global pharmaceutical industry over the past decade. The session focuses on the use of T3P in amidation and peptide coupling reactions, including both liquid-phase (LPPS) and solid-phase peptide synthesis (SPPS), while also highlighting its versatility in a broad range of other functional group transformations. These include nitrile formation, Swern-type alcohol oxidation, esterification, heterocycle formation, and more.

Additionally, Dr. Talbiersky also outlines the process and sustainability advantages of T3P compared with commonly used coupling agents, emphasizing its role as a safer, greener alternative in modern synthesis. Intended for API R&D teams, peptide and small-molecule developers, sourcing managers, and new product development professionals.