Article

The Importance Of Solid Fraction Data In Roller Compaction Operations

Source: Micromeritics Instrument Corporation
The Importance Of Solid Fraction Data In Roller Compaction Operations

Roller compaction is a continuous dry granulation process to increase the bulk density and uniformity of powders into free flowing granules used in downstream manufacturing operations. It is a complex procedure due to the diversity of available powder blends and the control and adjustment parameters involved in the process. In pharmaceutical operations, the Roller Compaction process has significant effect on particle size distribution, porosity, flowability in downstream operations, homogeneity, compactability and compressibility of the API, additives/ excipients. These factors influence dissolution profiles, disintegration time, and hardness of the produced solid dosage form.

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Micromeritics Instrument Corporation