The Innovative Flow-Through Solution For Continuous Viral Inactivation

Continuous viral inactivation (cVI) is a critical step in biopharmaceutical manufacturing, especially under low-pH conditions where maintaining consistent residence time and process control is challenging. This poster introduces the Pionic® Spin Incubator, a single-use device designed to deliver precise and reproducible incubation times in continuous downstream processing. Its curved flow path promotes radial mixing and narrow residence time distribution, enabling effective virus inactivation with ≥5 Log Reduction Values (LRV) in as little as 30 minutes. Data from multiple studies—including trials with bacteriophage Phi 6 and integration with Protein A capture—demonstrate the incubator’s ability to maintain target conditions across varying flow rates and viscosities.

Explore how the system supports scalable, low-dispersion performance and meets regulatory expectations for viral safety.