The Prevention Of Segregation Caused By Uncontrolled Agglomeration During The Drying Of A Pharmaceutical Powder In A Bolz-Summix® Conical Screw Dryer

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During start-up of a new Bolz-Summix® conical screw dryer, the bulk product agglomerated due to its sticky nature during a critical phase of the drying cycle. Down stream from the dryer, in the feed chute to the tabletting machine, segregation of the coarse product from the fine gave validation problems. This case study shows, that by slightly differing the process conditions during the drying stages, granulating could be eliminated, minimizing segregation.

Introduction
In many branches of industry, drying and mixing of particulate solids is an essential and critical process step to obtain the desired product specification. Various types of mixers and dryers are available in the process industry to meet the specific needs of each process. These mixers and dryers are basically divided between continuous operation and batch. The latter method of operation is often dictated by the process and product parameters, such as, multi purpose plants or where total batch integrity is required for quality and validation control as in the pharmaceutical and specialized food industry, enabling them to verify the product before it can be released on the market.

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