Newsletter | March 19, 2024

03.19.24 -- Turning Raw USP <1062> Data Into Valuable Insights

The Importance Of Steel Quality In Pharmaceutical Tablet Tooling Operations

In the design and manufacture of tablet compression tooling, nothing is more important than the quality of the materials being used. Explore how steel quality is defined and why it is the fundamental building block upon which all successive value-added steps are laid.

 

Tablet Compression Tooling: Land Or No Land?

Tablet land is the narrow, horizontal surface perpendicular to the tablet’s periphery, creating a junction between the tablet’s periphery and a convex cup. It can affect strength and wear characteristics of a punch as well as the severity of nicks on the punch. Learn what to consider when designing tablet land.

 

Intro To USP <1062> - What It Is And Why You Should Use It

Factors like powder flow, material characteristics, compression pressure, turret speed, etc., can affect the quality of the tablets and production run time. Knowing how to use USP <1062> helps manufacturers manage the variety of factors that can exacerbate production costs, or result in no product at all.

 

Closing The ‘Knowing-Doing’ Gap In R&D Using USP <1062> Data

Conducting trial runs can generate the valuable data you need to accept, or fail to accept, your hypothesis: Can your formulation be compacted into a robust, viable, marketable tablet? To ascertain these answers, you have to turn raw USP <1062> data into valuable insights.

 

Key To OSD Formulation Development Is In The Details

Pharmaceutical manufacturers facing challenges in tablet manufacturing environments are forming supportive vendor partnerships. Find out how you can successfully optimize the formulation and evaluate tablet robustness from tabletability and scalability studies while also allowing press operators to make press adjustments.

 

Considerations To Alleviate Sticking And Picking In Tablet Manufacturing

Sticking and picking problems are common in tablet manufacturing. Typically arising from either formulation or tablet design inadequacies, they can contribute to compression issues. Learn how compression tooling manufacturers can identify potential sticking and picking issues before tablet and tool designs have been finalized.

 

SOLUTIONS

Overcoming Solid Dose Formulation And Tablet Compression Issues

In this video from Virtual Pharma Expo February 2022, Robert Sedlock of Natoli Engineering explores tablet compression and formulation challenges. See how research, experimentation, and tableting expertise can provide proactive solutions to difficult tablet compression challenges.

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Tablet Characterization With Regulatory Compliance Method USP<1062>

This video demonstrates different punch cup configurations, a comparison of direct compression and dry and wet granulation techniques, and the impact on USP <1062> profiles in addition to a training demonstration on the tablet development process.

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IN THE NEWS

Natoli Announces Tablet Manufacturing Training Schedule For 2024

Natoli Engineering Welcomes Tablet Tooling Expert Todd Martin