Unravelling Immunological Depths: Exploring Oxazolone-Induced Delayed-Type Hypersensitivity Model

Delayed-type hypersensitivity (DTH) is a T-cell mediated immune response that typically occurs 24-72 hours after antigen exposure. In this process, antigen-presenting cells sensitize T-cells, which, upon re-exposure to the antigen, release cytokines. These cytokines activate local endothelial cells and macrophages, leading to inflammation and swelling at the site of exposure.

The oxazolone-induced DTH mouse model serves as a critical tool for studying the mechanisms and pathophysiology of DTH-associated chronic inflammatory diseases. This model is particularly useful in evaluating potential therapeutic candidates for chronic inflammatory conditions, bridging the gap between preclinical research and clinical applications aimed at treating these disorders.

At Aragen, our team successfully validated the oxazolone-induced DTH mouse model, creating a controlled environment to investigate the underlying mechanisms of the T-cell-mediated DTH response. By simulating conditions associated with chronic inflammatory diseases such as atopic dermatitis (AD), this model provides an invaluable platform for evaluating the efficacy of potential anti-inflammatory and immunosuppressive agents, advancing research into treatments for DTH-associated inflammatory skin diseases.