Utilizing The Colon Intestine-Chip To Investigate Mechanisms Of Gastrointestinal Disease

Organ-Chips developed by Emulate are proving to be a more effective tool than organoids in studying GI-related diseases, such as leaky-gut syndrome. The Colon Intestine-Chip, a microphysiological Organ-on-Chip model, successfully replicates the properties of human intestinal epithelium, providing valuable insights into barrier integrity. This technology allows researchers to delve deeper into the mechanisms behind leaky gut syndrome. In this presentation, experts from Emulate and The Johns Hopkins University School of Medicine discuss the benefits of Organ-Chips, the role of interleukin-22 in barrier function, the influence of mechanical forces on host-pathogen effects, and the creation of a reproducible cytokine-mediated barrier disruption model using interferon gamma.