Water Activity Testing: Advancing Moisture Determination Of Pharmaceutical Products

Moisture analysis plays a critical role in pharmaceutical product stability, yet traditional methods like gravimetric and Karl Fischer titration fall short in distinguishing between bound and unbound water. Water activity testing offers a more targeted approach by measuring only the free water fraction—an indicator closely linked to moisture-sensitive attributes such as microbial growth, chemical stability, and shelf life. Recognizing its scientific relevance, the United States Pharmacopeia has introduced Chapter <922> to formally establish water activity as a quality parameter in pharmaceutical moisture determination. This webinar explores how water activity testing is reshaping moisture analysis, particularly in freeze-dried and oral solid dosage forms.

Gain insight into the limitations of total water content measurements and learn how water activity provides a more predictive and non-destructive alternative.