Water Insoluble Drug Formulation

Delivering drugs in a water-insoluble formulation is a critical matter in therapeutic drug development. However, because a drug molecule has to be water soluble to be readily delivered to the cellular membrane while retaining its hydrophobic properties, issues surrounding water insolubility can postpone - or completely derail - important new drug development. Even much needed reformulation of currently marketed products can be significantly affected by these issues.

This book systematically describes the techniques used for water-insoluble formulations, providing step-by-step guidance as well as scientific background on drug and water properties and how they contribute to solubilization and dissolution. A world-class team of experts discusses how these issues are viewed - and solved - by key industry and R&D institutions.

Who Should Use This Book
This book provides a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students, and pharmaceutical and biopharmaceutical graduate students, to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.

Contents include:

• Solubility Theories, Steven H. Neau
  
• Prediction of Solubility, Yisheng Chen and Rong Liu
  
• Preformulation Aspects of Insoluble Compounds, Wei-Qin (Tony) Tong
  
• Biopharmaceutical Aspects of Water-Insoluble Drugs, John Crison
  
• Drug Solubilization by Complexation, Wei-Qin (Tony) Tong
  
• Solubilization Using a Cosolvent Approach, Jay Trivedi, and Mickey Wells
  
• Emulsions and Microemulsions for Drug Solubilization and Delivery, Pramod K. Gupta and John Cannon
  
• Micellization and Drug Solubilization Enhancement, Rong Liu, Negar Sadrzadeh, and Panos Constantinides
  
• Conventional Micelles, Rong Liu
  
• Liposomes and Lipid Systems, Rong Liu, John Cannon, and Yinghua Li
  
• Pharmaceutical Salts, Steven Neau
  
• Prodrugs, Steven Neau
  
• Particle Size Reduction, Robert Lee, James McShane, J. Michael Shaw, and Ray Wood
  
• Immediate Release Solid Dispersions for Oral Drug Delivery, Anita Nanda, Colin Rowlings, Nicholas Barker, and Pai-Chang Sheen
  
• Alteration of the Solid State of the Drug Substances, Michael Jozwiakowski
  
• Percolation and Other Solubilization Systems, Hans Leuenberger and Silvia Kocova El-Arini
  
• Soft Gelatin Capsule Development, S. Esmail Tabibi and Shanker L. Gupta

2000, Hardcover, 600 pages

Interpharm Press, Inc., 15 Inverness Way E., Englewood, CO 80112-5776. Tel: 303-662-9101; Fax: 303-754-3953.