What Everyone Needs to Know about Polymorphs

Polymorphs are crystalline materials that have the same chemical composition but different molecular packing. Polymorphs are one type of solid form. Other solid form types include solvates, hydrates, and amorphous forms. Some APIs may have only one or two known solid forms. Others may exist in twenty different forms, each having different physical and chemical properties. Sometimes the properties of two solid forms of a drug are quite similar. In other cases, the physical and chemical properties can vary dramatically and have great impact on pharmacokinetics, ease of manufacturing, and dosage form stability. This SSCI Application Note discusses the challenges and opportunities presented by different solid forms.

Published by: SSCI Inc.