Article | July 25, 2017

When Glass Vials Fail At Low Temperatures, Consider A Cyclic Olefin Polymer System

Source: West Pharmaceutical Services, Inc.
Biologics: When Glass Vials Fail At Low Temperatures, Consider A Cyclic Olefin Polymer System

Many biologic drugs, including cell and gene therapies, require low-temperature containment and storage that can range from refrigerated to cryogenic conditions. But, sub-ambient temperatures can be problematic for standard glass vials. If your biologic drug experiences vial breakage or does not maintain container closure integrity (CCI), a cyclic olefin polymer (COP) system may be a solution. COPs are proving to be a potential alternative for biologics due to their break resistance, ability to maintain CCI at low temperatures, and a lack of interactions with biologic drugs. COPs’ (with rubber stoppers) ability to maintain CCI at low temperatures has been demonstrated in two studies, which will be discussed in this paper.

West Pharmaceutical Services, Inc.