With Many Newer CHO Cell Lines Available, Why Continue To Use The CHO DG44 Variant?

Chinese hamster ovary (CHO) cells are a popular host for the production of biotherapeutics. Their enduring safety record, rapid growth, and ability to generate high product yields make them ideal for the commercial production of a wide range of biologics. There are multiple varieties of CHO cell lines constantly emerging to solve different challenges in the biopharmaceutical industry.

A variety of CHO cell lines are used as hosts in the production of biologics. Each offers unique advantages and is typically tailored to a particular biologic or group of biologics. For example, to enable post-translational modifications or promote the secretion of an extracellular protein. We discuss why we use the CHO DG44 variant for our CHO cell line development platform.