New PANalytical XRPD Data Supports High Throughput, High-Resolution Polymorph Screening
The X'Pert PRO MPD X-ray powder diffraction (XRPD) system from PANalytical (Almelo, The Netherlands) combines rapid data collection with unsurpassed data quality. This makes possible for the first time the use of a single analytical system for polymorph screening in combination with structural analysis.
Traditionally, screening instruments have been optimized for speed, providing only low-resolution data. As a result, the use of a second, high-resolution analysis technique has been common.
Now, sample data collected on Cimetidine (a histamine receptor antagonist), bovine insulin, and other complex organic materials, shows how the X'Pert PRO MPD takes high-resolution screening to a new level. The system offers high throughput, high-resolution screening that goes beyond pure polymorph identification to deliver semi-automatic crystallographic analysis.
The investigation of polymorphs - chemically identical substances in different crystallographic forms with possibly differing dissolution properties and varying bioavailability - is a key step in drug development. It aids the selection of a suitable solid form for development. In addition, because several polymorphs can have similar efficacy, it is essential that pharmaceutical companies discover and patent all polymorphs, hydrates and solvates of a drug.
XRPD is an accepted methodology for new product registrations and patent applications - an indexed XRPD pattern is frequently used to secure a patent.
For more information, visit: www.panalytical.com
About PANalytical
PANalytical is the world's leading supplier of analytical instrumentation and software for X-ray diffraction (XRD) and X-ray fluorescence spectrometry (XRF), with more than half a century of experience. The materials characterization equipment is used for scientific research and development, for industrial process control applications and for semiconductor metrology.
PANalytical, founded in 1948 as part of Philips, employs around 900 people worldwide. Its headquarters are in Almelo, the Netherlands. Fully equipped application laboratories are established in Japan, China, the USA, and the Netherlands. PANalytical's research activities are based in Almelo (NL) and on the campus of the University of Sussex in Brighton (UK). Supply and competence centers are located on two sites in the Netherlands: Almelo (development and production of X-ray instruments) and Eindhoven (development and production of X-ray tubes). A sales and service network in more than 60 countries ensures unrivalled levels of customer support.
The company is certified in accordance with ISO 9001:2000 and ISO 14001.
The product portfolio includes a broad range of XRD and XRF systems and software widely used for the analysis and materials characterization of products such as cement, metals and steel, nanomaterials, plastics, polymers and petrochemicals, industrial minerals, glass, catalysts, semiconductors, thin films and advanced materials, pharmaceutical solids, recycled materials and environmental samples.
Visit our website at www.panalytical.com for more information about our activities.
PANalytical is part of Spectris plc, the precision instrumentation and controls company.
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