Application Note

Zeta Potential Studies On The Surface Treatment Of Prefilled Syringe Barrels

Syringe-Staked-In-Needle-iStock-502347386 (002)

Prefilled syringes are available for more than two decades. They allow both the patient and the syringe manufacturers to deliver the needed medication conveniently.

Due to their small size, prefilled syringes are easy to use and to carry, the self-administration is easier for the patients and the risk of contamination with microorganism is reduced. In the manufacturing process advantages include the smaller drug volume as no overfilling volume as for vials is required to guarantee the correct dose. Additionally the fast and less preparation steps, if they come pre-sterilized, during the production are the biggest advantages.

The barrel of the prefilled syringes can be made of glass or plastic. At the moment the glass syringes are dominating the market but plastic syringes are getting more and more common. The major challenges in this industry for the manufacturers include the interaction of the material of the prefilled syringe with the drug.

Inner surface characterization of syringes helps to investigate the syringe base material, the quality of the coating on the glass or polymer or the interaction of the syringe surface and the drug. To characterize and test the inner surface of prefilled syringes the SurPASS 3 Measuring Cell for Prefilled Syringes was used.

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