News | February 23, 1999

Zonagen Announces Schering-Plough to Manufacture Vasomax

THE WOODLANDS, TEXAS (Feb. 23) BW HEALTHWIRE -Feb. 23, 1999--Zonagen Inc. (Nasdaq:ZONA)(PCX:ZNG) today announced that Schering-Plough Corporation (NYSE:SGP) has notified the Company that it has exercised its right to begin manufacturing finished product for Vasomax(R). Vasomax(R) is Zonagen's rapidly disintegrating oral formulation of phentolamine mesylate for the treatment of male erectile dysfunction that is currently under regulatory review by the U.S. Food and Drug Administration and the Medicines Control Agency in the U.K. In November 1997 Zonagen entered into a worldwide sales and marketing agreement with Schering-Plough for Vasomax(R).

Zonagen Inc. is engaged in the development of pharmaceutical products for the reproductive system, including sexual dysfunction, urology, contraception and fertility. Through its wholly owned subsidiary, Fertility Technologies Inc. (FTI), Zonagen sells devices, instruments and supplies to fertility specialists, obstetricians and gynecologists.

A copy of this press release may be obtained via facsimile by dialing 1-888-329-0920 or via the Internet by accessing www.zonagen.com.

Any statements that are not historical facts contained in this release are forward-looking statements that involve risks and uncertainties, including but not limited to those relating to the uncertainties of clinical trial results and FDA approval in the U.S., and approval of regulatory authorities in other jurisdictions, substantial dependence on one product, uncertainty of protection for patents and proprietary technology, limited sales and marketing experience and dependence on collaborators, manufacturing uncertainties and reliance on third parties, competition and technological change, and other risks identified in the Company's Annual Report on Form 10-K for the year ended December 31, 1997, as filed with the Securities and Exchange Commission.

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CONTACT: Zonagen Inc., The Woodlands 

          Jean Anne Mire, 281/719-3491

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