EDUCATIONAL ARTICLES AND RESOURCES

• Guidance For Lab Washer Cleaning In Life Sciences

  The principal concern for any scientist or technician working in the laboratory is that glassware, instruments, and equipment be free of interfering residues.

• The Benefits Of Aqueous Critical Cleaning In Medical Device Manufacturing

  The use of aqueous cleaning in medical device manufacturing can provide numerous benefits in terms of efficacy, minimal surface contact and reduced residue potential, and easier cleaning validation.

• Optimize Your Critical Cleaning Process And Ensure Results

  Getting the best results from any cleaner requires proper mixing and cleaning procedures. This article includes mixing directions for aqueous cleaning detergent and methods for monitoring performance.

• The Benefits Of Aqueous Critical Cleaning In Pharmaceutical Manufacturing

  The use of aqueous cleaning in pharmaceutical manufacturing can provide numerous benefits in terms of efficacy, minimal surface contact, reduced residue potential, and easier cleaning validation.

• Cleaning Validation For Medical Device Manufacturing

  Cleaning validation or verification is a necessary regulatory compliance step in medical device manufacturing and reprocessing. Support from the cleaner manufacturer can save time and money.

• Pharma Manufacturers Should Get Cleaning Validation Support From Supplier

  Cleaning validation is a necessary and time-consuming part of manufacturing pharmaceuticals. The validation process can be expedited and cost reduced if the cleaner supplier can provide support.

• Recommended Cleaning Detergents For Life Sciences Cleanrooms

  For cleanroom cleaning, users should consider liquid concentrate detergents to avoid the creation of powdered clouds in the classified environment.  

• What Does Free Rinsing Detergent Mean?

  Q. What does free rinsing detergent mean?

• Removing Silicone Grease From Syringes

  A faster and more efficient method to remove silicone grease from syringes is to use very hot water for cleaning and very hot water for rinsing. 

• Removal Of Water Spots And Oil On Pharma And Lab Glassware

  It is very important to pay attention to how glassware and equipment is loaded in to a washer so as to minimize trapping any water from cycle to cycle.

• Cleaning Detergents For Stainless Steel Dishwashers

  Q. What kind of cleaner options can you provide which can be safely be used in stainless steel dishwashers?

• Residue Testing Using UV And HPLC Methods

  Q. We are interested in Alconox® detergent for cleaning during our production process. Since we produce several kinds of medicine, we need to be sure Alconox® do not leave any residue after cleaning. We want to test the residue of Alconox® by UV method or HPLC method. Could you send reference or guide on these methods?

• Residue Testing With pH Strips

  Q. Can I use pH paper to confirm cleaning and rinsing of labware to comply with lab accreditation requirements?

• Cleaning pH Probes And Dissolved Oxygen Probes

  Dissolved oxygen and pH probes used in fermentation vessels can get develop buildup from the fermentation media that degrades the probe performance and increases the likelihood of contamination.

• Inorganic Residue Removal Via Clean-In-Place

  As a rule of thumb, alkaline detergents are best for organic, oily residues, while acidic detergents are best for inorganic residue like salts and oxides.

• Detecting Residues In Cleaning Validation

  When beginning cleaning validation, a company must identify the residues to be tested and then select the best detection method.

• Nanotechnology Critical Cleaning For Quality & Safety

  Nanotechnology is currently employed across a wide range of industrial, research, and academic applications. Stringent cleaning protocols are essential to the successful fabrication of nanotechnology particles, structures, and systems.

• How To Detect Detergent Residue To Maintain Laboratory Accreditation Guidelines

  The following test procedures are suitable for detecting detergent residues resulting from improper rinsing and can be used to meet laboratory accreditation guidelines and questionnaires such as the College of American Pathologist program of State water lab accreditation programs.

• The Role Of pH And Residue In Pharmaceutical Cleaning

  A great deal is known about how pH affects aqueous critical cleaning. Typically, alkaline cleaners are used on oily residues and acidic cleaners are used on inorganic residues.

• Factors To Consider When Cleaning Pharmaceutical Equipment

  Typically pharmaceutical operations require transition from bench scale R&D to pilot studies to full-scale manufacturing.

• The 7 Most Important Questions To Ask When Selecting An Aqueous Cleaner

  Today's aqueous critical-cleaning detergents are blended for specific applications. Substrate, degree of soil load, and cleaning processes are all important considerations when selecting a detergent. 

• What You Should Know About Pharmaceutical Cleaning Validation

  This paper outlines the basics of cleaning validation, as well as the kinds of support services you should seek from suppliers of critical cleaning products in order to optimize your cleaning validation process.

• Minimizing Surface Residues With Aqueous Cleaning

  The benefits of employing aqueous cleaning in pharmaceutical manufacturing are numerous. Virtually any pharmaceutical manufacturing equipment from tablet press to a stainless steel mixing tank can achieve their defined critically clean criteria using aqueous cleaning. Typically aqueous cleaners are formulated to ensure maximal cleaning performance by using key ingredients such as surface active agents (surfactants) that are excellent wetting agents that allow the cleaning solution to penetrate into crevices while getting under soils to allow for removal. Often very dilute solutions of aqueous cleaner effectively removes even worst case substances off a variety of hard surfaces including stainless steel, glass, plastic, or porcelain. By Malcolm McLaughlin

• A Guide To Labware Washer Cleaning

  The principal concern for any scientist or technician working in the laboratory is that glassware, instruments, and equipment be free of interfering residues.

• Aqueous Critical Cleaning: Applications In Medical Device Manufacturing

  Aqueous cleaners are suitable for a range of cleaning methods commonly employed in medical device manufacturing including ultrasonic, manual, soak and automated. The range in formulation from acidic to basic, high emulsifying to low foaming, and availability of liquid concentrates to powder blends ensures that a cleaner can be found to clean whatever residues are encountered using whatever the cleaning method is being used. Submitted by Alconox
• How To Choose Alkaline Or Acid Pharmaceutical Cleaners

  A great deal is known about how pH affects aqueous critical cleaning. The first step is for you to identify the residue that needs to be removed and then determine the optimal pH range that will remove it. By understanding the structure, functional groups, molecular polarity, solubility and molecular weight of the residue being removed, it is possible to determine if an alkaline or acidic cleaner would work best for a given cleaning method. Submitted by Alconox