Here we review the information in European Pharmacopoeia (EP) General Chapter 5.1.2, concerning BIs, which is more detailed and covers a wider scope than the previous version.
We review what to do should you ever find yourself in the situation where the probes indicate conditions that would render killed BIs, yet the units are testing positive.
We highlight vapor hydrogen peroxide (VH2O2) biological indicators (BIs) including necessary physical characteristics of the BI unit, BI types, proper BI placement, and challenges encountered.
This field guide uses current published resources to provide clarity and direction regarding best practices for validating decontamination processes using VH2O2.
We discuss the three general BI types used for monitoring the VH2O2 cycles and directions on their proper placement in the isolator.
We discuss the concept of using triplicate biological indicators (BIs), not as a reaction to having obtained an unexpected growth-positive BI in your vaopr hydrogen peroxide cycle, but as a proactive measure.
We review the potential benefits and difficulties of using Vapor Hydrogen Peroxide (VHP) in decontamination and sterilization.
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