Natoli White Papers

  1. Understanding The Importance Of Punch Length And Cup Depth
    4/4/2019

    This paper describes how to understand punch length, how to measure it correctly, and how wear affects length and tablet consistency. It also addresses the importance of specifying cup-depth tolerances.

  2. Approaching Tablet Formulation Step-By-Step To Avoid Risks
    11/6/2018

    All formulators need a methodology that gives them reliable and useful information to identify problems before tablet manufacturing begins.

  3. Inspecting On The Edge – Understanding Punch Tip Wear
    3/26/2018

    Avoid production quality-related issues by understanding and knowing how to identify the most common causes of punch tip edge wear.

  4. Tool Life Expectancy In Pharma Manufacturing
    3/26/2018

    Individual punches and dies may represent a small portion of production costs in relation to the purchase and maintenance of the equipment, such as fluid bed dryers and tablet presses.

  5. R&D To Pharmaceutical Product: How To Reduce Costly Scale-Up Problems
    6/1/2017

    When scaling a new drug formulation from the development side of R&D into manufacturing, there is often a reality check with respect to process scale- up and performance of the formulation at production levels. By Chuck Kettler, Director, Natoli Scientific of Natoli Engineering Company, Inc.

  6. How To Reduce Costly Scale-Up Problems in Solid Dose Manufacturing
    4/4/2017

    Problems with capping/lamination and sticking/ picking are often first realized when a formulation is introduced to a level of compression required to supply market demand.

  7. Avoid Tablet Production Problems In The Formulation Development Process
    10/13/2016

    Providing support in all aspects of the tablet compression process should be expected from your tooling and tablet press partner.

  8. The Importance Of Land Width On Pharmaceutical Tablet Design
    6/10/2016

    Tablet land is beneficial to add strength and durability to the punch tip. But, this hand land may be perceived as making it more difficult to coat the tablet.

  9. The Importance Of Steel Quality In Tablet Compression Tooling
    5/14/2015

    In the design and manufacture of tablet compression tooling, nothing is more important than the quality of the materials being used.

  10. 8 Ways To Reduce Tablet Manufacturing Costs

    It's no surprise that in today's struggling economy, companies are facing budget cuts across the board. In an effort to help our customers address these challenges, we put together this list of 8 Ways to Reduce Tablet Manufacturing Costs.