Package Inspection White Papers & Case Studies

  1. Understanding Sensitivity Principles For Industrial Metal Detectors
    2/7/2019

    This guide explains the concept of metal detector sensitivity, key factors that impact it, and why a small difference in spherical sensitivity performance can mean a big difference in contaminants detected.

  2. How To Properly Test Your Industrial Metal Detector
    2/7/2019

    This white paper provides an explanation of the differences between validation, verification and routine performance monitoring as well as an overview of recommended test methods for different types of metal detection systems.

  3. Using Laser-Based Headspace Moisture Analysis For Rapid Nondestructive Moisture Determination Of Sterile Freeze-Dried Product
    12/28/2018

    Rapid water vapor determination with an optical method could replace the slow destructive traditional methods for the moisture analysis of freeze-dried product. A description of industry applications of headspace moisture analysis including freeze drying cycle optimization, lyo chamber moisture distribution mapping, and 100% moisture inspection of commercial freeze-dried product.

  4. Container Closure Integrity Testing For Sterile Vial Products In Deep Cold Storage
    12/28/2018

    A vaccine-focused biotechnology company approached LIGHTHOUSE to help investigate a phenomenon observed in liquid vaccine product stored at -80°C. During QC testing, a number of vials were found to have an overpressure. This phenomenon represented a serious safety risk and LIGHTHOUSE was asked to support an investigation to identify the root cause.

  5. Detection of Microbial Contamination In Sterile Containers Using Headspace Analysis
    12/28/2018

    Laser-based headspace provides yet another alternative approach for detecting microbial contamination in sterile pharmaceutical product allows for quicker, more sensitive, accurate, and reproducible test results when compared with conventional, growth-based methods.

  6. Headspace Oxygen Monitoring And Container Closure Integrity Testing Of Pre-Filled Syringes
    12/28/2018

    This application note describes how laser-based headspace analysis is used for the rapid non-destructive determination of headspace oxygen levels in pre-filled syringes. Data is presented demonstrating two major applications of this technique: 1) headspace oxygen monitoring on a pre-filled syringe line filling oxygen-sensitive product, and 2) container closure testing of pre-filled syringes.

  7. Protecting Dry Pharmaceutical Product From Moisture Permeation
    12/27/2018

    How non-destructive headspace analysis information can be critical for QC groups performing stability studies, or for packaging development groups responsible for choosing the optimal primary packaging configuration.

  8. Lyo Chamber Moisture Mapping
    12/27/2018

    Rapid non-destructive headspace moisture analysis from LIGHTHOUSE enables fast moisture determination of statistical numbers of lyo samples.

  9. Using Non-Destructive Headspace Analysis To Address Customer Complaint
    12/27/2018

    In cases where oxidation of the formulation causes discoloration and eventual degradation of the product, non-destructive headspace analysis tests can give deep insight into the root cause. Since the samples are not destroyed by the headspace analysis, further testing can be done to accurately correlate headspace conditions with other product characteristics.

  10. Headspace Oxygen Formulation Oxidation
    12/27/2018

    Application of the LIGHTHOUSE headspace method demonstrates how ability to quickly and accurately determine headspace oxygen levels saves time and enables deep insight into formulation stability. In addition using a non-destructive laser-based headspace analysis saves valuable product samples and avoids clean-up and contamination issues.