CDMO Horror Stories And How To Avoid Them
Considerations when choosing a contract manufacturer for drug substance development or finished dosage forms.
Patient-Centric Drug Design — A Clinical & Academic Perspective
Most issues in pediatric drug development arise from the fact that drugs are traditionally developed for adults and not children. Dr. Meyers shares the delivery hurdles and recent improvements in pediatric drug development.
Why The Shift From Batch To Continuous For Pharmaceutical Oral Solid Manufacturing Is Now Upon Us
There has been intense interest and emphasis being given to the continuous OSD manufacturing process as an alternative or addition to the traditional batch manufacturing process.
How To Increase Regulatory Flexibility And Tablet Production Efficiency
The goal of every pharmaceutical developer is to create quality products that generate consumer satisfaction, require low cost, and have low risk.
The Key To Continuous Manufacturing
Ivo Backx points out that integration of all process automation architectures is essential if continuous manufacturing is to be rolled out successfully.
Accurate Bulk Density Measurement Maximizes Solid Dose Production
The most popular dosage form in the pharmaceutical industry is the compressed tablet. Fully two-thirds of all prescriptions are dispensed in a solid dosage form and half of these are compressed tablets. While it looks simple in its white or colored form, the compressed tablet is a complex mix of the active drug and a host of excipients.
Guest Column: Powder Characterization Techniques For Tableting Applications
Simple to administer, tablets are a feature of every day life. Tablet production has a history dating back more than a century, but retains its ability to frustrate. The drive towards faster production speeds, increasingly potent actives and the adoption of complex tablet structures present modern day tablet manufacturers with significant challenges. Understanding how to manipulate the properties of the blend towards better processing performance and high quality of final product is essential. By Tim Freeman, Freeman Technology
Tutorial: New Technologies Protect Pharmaceuticals Against Counterfeiting
Anticounterfeiting and traceability are different
problems requiring different solutions. On the
one hand, traceability requires standardization
and interoperability among the various manufacturers
and the intervening third parties within the supply chain
up to the dispensing point. By Roland Meylan, AlpVision
Poster: Taste Masked Ondansetron Orally Disintegrating Formulations With EUDRAGIT® Polymers
Orally disintegrating tablets (ODT) continue to make
inroads into the market for solid dosage forms owing
to its ease of use, the potential for increased patient
compliance and a way to extend the product life cycle
of a drug. By Evonik Röhm GmbH
Article: Better Wet Granulation: Development, Scale-Up And Manufacture
Wet granulation is a common unit operation in the pharmaceutical industry yet accurate endpoint detection remains a challenge. Here we examine the contribution that dynamic powder rheometry can make, highlighting its ability to detect the transition from wet mass to granulate with the required sensitivity. Quantification of this transition point, with a measure that is independent of process scale, accelerates development and scale-up and improves manufacture. By Tim Freeman, Freeman Technology