03.20.25 -- Achieve Success In Upstream Bioprocessing: Prioritizing Productivity, Consistency, And Cost-Effectiveness

Malaria remains a global health crisis. New vaccines, including transmission-blocking candidates like Pfs230D1M, offer hope. This study compares single-use and steel fermentors, analyzing their effectiveness and scalability for efficient, cost-effective Pfs230D1M production.

Vaccine production demands efficient, large-scale adherent cell culture. This study explores Vero cell scale-up, transitioning from static cultures to bioreactors using microcarriers. Optimization across platforms, including T-flasks and single-use bioreactors, is key to maximizing productivity while minimizing cell stress.

Intensified cell culture processes are pushing the limits of legacy single-use bioreactors. See how the DynaDrive S.U.B addresses these challenges by allowing for fewer vessels, leading to reduced contamination risk and operational costs and streamlining scale-up from 50 to 5000L.

Optimizing harvest in bioprocessing is crucial for efficiency and sustainability. Balancing factors like consumable use, cleanroom footprint, and processing time impacts operational costs and environmental impact. This guide details five considerations for making informed, effective harvest decisions.

Researchers often struggle to scale their manufacturing processes to meet clinical and commercial needs. In this application note, researchers explore scaling lentivirus manufacturing for vaccines and gene therapy using the Gibco CTS LV-MAX Production System. The study provides data on producing and clarifying lentiviruses at a 50 L scale.

Experience the next level of bioprocessing with DynaDrive Single-Use Bioreactors. This innovative system delivers unmatched design, scalability, and performance for optimal cell culture. Achieve high cell densities across all volumes with streamlined processes and robust hardware.

The HyPerforma™ S.U.F. offers optimal fermentation conditions comparable to traditional systems, streamlining scale-up and process development.  Engineered for efficiency in 30L and 300L sizes, it delivers cost savings and boosts productivity.