Upstream bioproduction has seen a substantial movement in the industry toward single-use systems. This has been driven primarily by the need to reduce contamination risk and cleaning requirements when compared to stainless steel systems, and to allow for faster changeover of equipment between batches. At the same time, bioprocessing manufacturing processes have matured significantly, and intensification of cell culture processes has pushed the limits of these legacy single-use systems. In recent years, Thermo Fisher Scientific has brought enhancements to the Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.) platform with 5:1 S.U.B. and enhanced S.U.B. options, which have allowed for higher turndown ratios and optimized mixing and gassing strategies for intensified processes. Now Thermo Fisher Scientific has launched a next-generation bioreactor for the biopharmaceutical industry with the Thermo Scientific™ HyPerforma™ DynaDrive™ S.U.B.