Analysis And Characterization Of GLP-1 Receptor Agonists: Your Guide To Precise And Robust Separation Methods

As demand for GLP-1 receptor agonists surges, driven by their success in treating type 2 diabetes and obesity, drug manufacturers face mounting pressure to ensure product quality, safety, and regulatory compliance. This application note offers a comprehensive overview of analytical strategies for characterizing GLP-1 RAs, with a focus on critical quality attributes (CQAs) such as identity, purity, stability, and safety. It explores advanced techniques, including RPLC-MS, amino acid analysis, peptide mapping, and SEC-MALS, providing detailed workflows for impurity profiling, stability testing, and aggregate characterization. Highlighting the challenges of synthetic and recombinant peptide production, discover system configurations and column technologies that are optimized for robust and reproducible separations. Whether you're developing new formulations or performing quality control, this resource equips you with the tools and insights to navigate the complexities of GLP-1 RA analysis.

Access the full application note to strengthen your analytical workflows and stay ahead in peptide therapeutic development.