In this segment from the Pharmaceutical Online Live event, “Analytical Strategies for High-Volume GLP-1 Manufacturing” our panelists talk about reducing release timelines with NIR spectrophotometry, the biggest bottlenecks to release testing, AI assisting in release testing and how companies are approaching real time release testing.

In this segment from the Pharmaceutical Online Live event, “Analytical Strategies for High-Volume GLP-1 Manufacturing,” the panelists discuss the issues with variability that can arise with scale-up to multi-tonne quantities, the surprises that came with a high global demand and the biggest bottlenecks to scale-up.

In this segment from the Pharmaceutical Online Live event, “Analytical Strategies for High-Volume GLP-1 Manufacturing” our panelists talk about the element of GLP-1 manufacturing received the least attention but is the most important operationally—the starting material.

In this segment from the Pharmaceutical Online Live event, “Analytical Strategies for High-Volume GLP-1 Manufacturing” our panelists talk about quality control, including ensuring a quality by design process, optimizing risk analysis, and continuous improvement.

In this segment from the Pharmaceutical Online Live event, “Analytical Strategies for High-Volume GLP-1 Manufacturing” our panelists discuss adjustment to analytical strategies in increased GLP-1 manufacturing such as monitoring for aggregates, changing sampling rates, NIR spectrophotometry, reducing human interaction, and how analytical throughput changes from injectable peptides to oral peptides.

Structurally similar impurities can be difficult to separate in GLP-1 therapeutics. See how column chemistry influences selectivity and supports more confident profiling for peptide-based drugs.

As peptide therapeutics grow more complex, impurity profiling demands greater chromatographic confidence. See how robust reproducibility can support reliable GLP-1 receptor agonist analysis.

Native SEC‑MALS offers a calibration‑free way to accurately characterize peptide oligomers, helping scientists distinguish true higher‑order structures while avoiding bias.

Microflow chromatography offers a practical way to boost GLP‑1 assay sensitivity while cutting solvent use. See how 1.0 mm columns improve peak response without sacrificing chromatographic performance.

Gain insight into how a systematic approach reveals impurity behavior, strengthens selectivity, and refines chromatographic conditions to build a reliable degradation method for a GLP‑1 agonist.

Look at how denaturing SEC‑MS uncovers low‑level oligomers and truncated variants in GLP‑1 peptides, offering clarity on impurity profiles and supporting confident assessment of molecular integrity.

Improve purification workflows for complex GLP‑1 peptides with practical guidance. Learn how to boost resolution, uncover hidden impurities, and increase yield across analytical and preparative workflows.

Discover how to strengthen peptide bioanalysis, from improving recovery and reducing non‑specific binding to optimizing LC‑MS sensitivity and streamlining data review to achieve reliable quantification.

Discover a detailed guide to characterizing GLP-1 receptor agonists that covers advanced LC-MS and SEC-MALS workflows for impurity profiling, stability testing, and aggregate analysis.

GLP-1 receptor agonists are revolutionizing therapeutics beyond diabetes. Explore analytical innovations that ensure safety and efficacy as these peptides expand into multiple treatments.

Discover how integration transforms lab workflows to enhance molecular characterization, streamline data management, and ensure compliance for superior data integrity and operational efficiency.

Discover how to enhance your peptide analysis by integrating UV and mass spectral data into a single, streamlined workflow to boost data confidence and lab efficiency.

Explore a UPLC-UV method using Empower 3 Software to assess synthetic peptide purity. Learn how integrated tools streamline impurity tracking, data reporting, and compliance in peptide analysis workflows.

GLP-1 receptor agonists are transforming diabetes and weight loss treatment. Discover how to enable precise impurity analysis and characterization of complex, fatty acid-modified peptide therapeutics.

Discover how SEC-MALS enables precise characterization of GLP-1a therapeutics to ensure formulation integrity and enhance safety, efficacy, and regulatory confidence.

Achieve ultra-sensitive glucagon quantification with ionKey/MS, μElution SPE, and advanced MS fragmentation to deliver low LOD, reduced sample loss, and enhanced confidence in results.

Discover a highly sensitive and reliable LC-MS/MS method for quantifying exenatide in plasma that is powered by advanced sample prep and optimized column chemistries.

Discover how LC-UV/MS workflows help overcome analytical challenges in GLP-1 analog development to streamline impurity identification and boost lab efficiency in research.

Explore a streamlined LC-UV/MS workflow that empowers labs to meet rising GLP-1 drug demand with faster, more informed decisions that enhance compliance and impurity detection efficiency.

Biologics are transforming medicine, with semaglutide leading the way. Discover how an automated LC-MS/MS workflow enables high-sensitivity quantification of peptides in plasma.

Column temperature critically affects the reversed-phase separation of fatty acid-modified GLP-1 RAs and impurities. Learn how precise control enhances resolution and reproducibility.

Explore the performance of four column chemistries for RPLC-UV impurity analysis of liraglutide and semaglutide, which offers practical guidance for method development in peptide-based therapeutics.

Discover a robust, evaporation-free method for analyzing liraglutide in human plasma using LC-MS/MS to ensure high sensitivity, reproducibility, and improved analyte recovery.

Explore a validated LC-MS/MS method for precise Semaglutide quantification in plasma, which features enhanced sensitivity, peak definition, and reproducibility using innovative technologies.

Discover a streamlined LC-MS/MS workflow for Fc-containing therapeutics like dulaglutide to enable precise quantification with LLOQ as low as 1 ng/mL through automated, efficient assay development.

Gain insight into a robust LC-MS/MS method for quantifying therapeutic peptides that supports contamination control and cleaning validation to ensure product safety and integrity.

Discover a sensitive, selective, and robust LC-MS method for quantifying semaglutide in plasma with advanced sample preparation and detection technologies for accurate results in bioanalytical research.

Discover how an innovative technology enhances LC-MS analysis of GLP-1 receptor agonists by minimizing peptide loss and improving assay sensitivity and consistency.

Explore a novel HPLC-UV/MS method for analyzing GLP-1 analogs to address critical challenges in peptide separation, impurity detection, and performance for improved reproducibility.

Liquid chromatography revolutionizes science with precision. Discover a technology that leads the charge in enhancing HPLC performance for breakthroughs in health, safety, and environmental research.

By embracing data-driven insights, companies can confidently navigate complexities, reduce risks, and deliver trusted products to global markets.

Gain expert insights into the driving forces behind change management, the associated obstacles within a QC lab, and best practices for guiding change when implementing new technology or procedures.

Here, the USP Tryptophan monograph is evaluated using two HPLC systems. Stability, sensitivity, and performance improvements are assessed with a diffusion-bonded mixer versus standard configurations.

Learn about the challenges in HPLC separations of metal-sensitive analytes and how one innovative solution provides improved separations of analytes that adsorb on metal services.

Understand the ease and added compliance provided in using embedded software tools in the replication or transfer of an existing method to a new HPLC system.

What does two decades of impact look like? Read on to learn about the UPLC system that has redefined industry standards for runtime, resolution, peak shape, and peak capacity.

Successful method migration to a new HPLC system can be challenging. The gradient USP method for Quetiapine Fumarate Impurities was analyzed on two legacy HPLC systems and on modern technology.

The USP monograph of atorvastatin requires adherence to strict criteria for the assay analysis of atorvastatin. In this study, several strategies were implemented to meet the stipulated USP monograph criteria.

The system suitability solution sample from the cetirizine hydrochloride organic impurities USP monograph was used to assess the impact of the needle wash and needle wash design on HILIC separations.

The USP monograph for Azithromycin Organic Impurities was chosen as a representative method. Explore the challenges of this method, and compare the results obtained across a number of different HPLC systems.

The rising popularity of vitamin supplements necessitates ensuring product content accuracy. In this study, we demonstrate the ability to achieve the same quantitative results on legacy and newer HPLC systems.

Soft drinks often contain one or more additives, such as benzoate or sorbate, and/or acesulfame K, saccharin, or aspartame. In this study, a HPLC System was employed for the analysis of these additives.

This study demonstrates the successful scaling and migration of a hydrophilic interaction liquid chromatography method for ribavirin analysis from a sub-2 µm column to larger particle sizes on different HPLC systems.

The ability to migrate methods across HPLC systems is essential as systems are updated. Review a normal phase method that provides a means for quantification of tocopherols in vitamin supplements.

In many regulated labs, there is a need for reliable, robust HPLC systems capable of operating for extended periods of time to accommodate the demand for high instrument utilization and product timelines.

This study established a robust HPLC method for analyzing the major active compounds in ashwagandha. Explore the impact of an optimized extraction method using ultrasound and ethanol/methanol/water solvent mixture.

In this study, the injection precision of an Alliance iS HPLC System was evaluated using four compendial HPLC methods from the USP with challenging method conditions and strict system suitability criteria.

See how you can achieve seamless method transfer from systems equipped with quaternary or binary solvent managers, maintaining separation selectivity without time-consuming method re-optimization.

Explore results from a study assessing the ability of a modern HPLC system to support manufacturing labs with the routine downstream analysis of DNA/mRNA therapeutics using SEC.

This study assesses a modern HPLC system within a routine QC testing environment focused on peptide-size biopharmaceuticals.