
ABOUT WATERS CORPORATION
Waters Corporation, a global leader in analytical instruments, consumables, and software, has pioneered innovations in chromatography, mass spectrometry, and thermal analysis serving the life, materials, and food sciences for more than 60 years. We ensure the efficacy of the medicines we take, the safety of the food we eat and the water we drink, and the quality of the products we use every day. With more than 7,800 employees worldwide, Waters operates in over 35 countries, including 14 manufacturing facilities, and has products available in more than 100 countries. Together with our customers, in labs around the world, we deliver scientific insights to improve human health and well-being, helping to leave the world better than we found it.
ALLIANCE IS HPLC SYSTEM
FEATURED ARTICLES
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Learn in detail about the impact of change management on the pharmaceutical industry and how it ensures innovations and improvements are managed effectively.
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This article collection, a collaborative effort between Waters Corporation and Pharmaceutical Online, offers a vivid portrayal of innovation and new efficiencies shaping the modern lab in pursuit of progress.
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We demonstrate how MaxPeak HPS Technology enhances the analysis of intact proteins, peptides, nucleotides, glycans, and cell culture, addressing evolving biopharmaceutical therapeutic needs.
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The road to becoming a lab of the future can be challenging, with many obstacles along the way. Gain insight into the roles digital transformation and connectivity will play in the lab of the future.
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Learn about the hardware changes that allow for scaling and modernization of chromatographic methods and how mismatching particle size and liquid chromatographic systems can result in poor performance.
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Explore the latest updates to the USP <621> guidelines that involve changes to the allowable modifications to gradient methods and updates to system suitability parameters.
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Learn how Empower Software addresses modifications to certain calculations and maintains relevant naming conventions and calculations to help customers update SOPs to prevent disruption to operations.
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Are you looking to update a validated liquid chromatography method? This guide offers a step-by-step approach to adjusting your methods that can help you achieve your goals and save time in the process.
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Discover how analytical instrumentation, chemistries, and purpose-built informatics from Waters Corporation can help you eliminate the issues associated with older technology and outdated manual processes.
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Here, we examine the cause and impact of common errors in Quality Control (QC) labs, the strategy for reducing those errors with an intuitive chromatography system, and more.
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Explore results from an experiment analyzing the USP monograph for cetirizine hydrochloride assay and organic impurities on two legacy HPLC systems and migrating them to the Alliance™ iS HPLC System.
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Learn more about how the Quality Control team at Almac Sciences developed processes and strategies to help ensure a high quality of safe and effective products while also maximizing efficiency.
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A partnership facilitated capacity, efficiency, and compliance of pharmaceutical manufacturing and analytical service increases for a prominent CDMO.
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Discover a single HPLC method that can replace several separate methods for the analysis of the assays and organic impurities of active pharmaceutical ingredients naphazoline hydrochloride and pheniramine maleate.
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Carryover performance across various HPLC systems was assessed using a scaled method based on the USP monograph for chlorhexidine hydrochloride organic impurities. Explore results as well as mitigation strategies.
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An isocratic USP monograph for ibuprofen and related organic impurities was used to assess a method migration between HPLC systems. Explore results that demonstrate the ability to migrate methods.
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Learn how the gradient method allowances described in USP General Chapter <621> Chromatography, combined with a modern HPLC system, were employed for the USP monograph separation of abacavir sulfate.
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Explore three perspectives on the capabilities and adoption of MAM workflows within the biopharmaceutical industry in addition to MAM resources for process and product control of biotherapeutic proteins.
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Multi-Attribute Method analysis using liquid chromatography – mass spectrometry has emerged as a valuable tool for drug discovery, development, process monitoring and quality control.
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With industry-leading scientific expertise and customer support, we have pioneered solutions to some of the most pressing challenges facing customers interested in adopting MAM into their organizations.
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Explore the utility of electron capture dissociation (ECD) on the SELECT SERIES Cyclic IMS instrument for unambiguous assignment of glycosylation site locations for 11 Oglycopeptide species of ENBREL.
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Learn about a premier system offering a flexible LC platform that can be broadly deployed across labs to support the analytical needs in the development and manufacturing of biotherapeutics.
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This notebook from the Biopharmaceutical Scientific Operations Team at Waters illustrates key attribute monitoring workflows to improve and streamline MAM analysis of biotherapeutic proteins.
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Employing the Multi-Attribute Method based on liquid chromatography-mass spectrometry analysis represents a critical advancement in evaluating the complexity of biotherapeutic molecules.
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Learn about a global interlaboratory method transfer study of a USP impurities method that was conducted at eight participating sites.
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Understand how system factors like dwell volume and extra-column volume contribute to method performance across labs and how this knowledge can increase the success of method transfer.
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Method validation is a time-consuming activity prone to human error. Find out how a method validation manager can provide a single, comprehensive solution for your validation activities.
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Effective method development of LC and LCMS methods typically involve highly experienced scientists with a wealth of knowledge that has been handed down throughout their organization. For some particularly challenging and complex mixtures this experience may not be enough. Learn how Waters leveraged a generic systematic protocol to separate a variety of APIs in a single run.
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We demonstrate an automated, compliance-ready liquid chromatography-mass spectrometry (LC-MS) workflow for sequence confirmation of oligonucleotides and their impurities.
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Explore a comprehensive LC-MS methodology, workflow, and batch analysis software that allows bioprocessing engineers to quickly and easily run and process large number of samples.
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We present a fully automated workflow for sample preparation and LC-MS analysis of mAbs obtained directly from complex samples such as spent cell culture media including host cell protein.
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We explore a streamlined integrated workflow for data acquisition, processing and reporting of deconvoluted mass data for biotherapeutics, deployable in regulated and non-regulated environments.
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We demonstrate that comparable chromatographic profiles and relative quantitation can be achieved with the larger particle size column at HPLC-compatible pressures, albeit with an increase in sample load, mobile phase use, and most importantly, analysis time.
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Explore how we improved releasing N-glycan analysis in biotherapeutic development, which can help develop robust and unbiased glycan assays for biotherapeutic development, manufacture, and release.
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Discover how combining this system with modern UHPLC columns could make data more accurately interpreted through greater efficiency, selectivity, and enhanced resolution.
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This study examines technological advancements in both the column hardware and packed particle chemistry of solution that provides extended column lifetimes when using physiological pH mobile phases.
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By having better control over our manufacturing processes we are able to minimize the risk of out-of-specification intermediates all the way through to final products.
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We demonstrate the performance of a new column technology designed to provide a holistic solution to the problems of undesired secondary interactions in SEC.
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Discover the most impactful standards in liquid chromatography (LC) for biotherapeutics. The standardizations include methods, columns, standards, and robustness.
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Performance Stability Of CORTECS 2.7 μm Columns Following Repeated Injections Of Precipitated Plasma
We review a column made using optimally packed solid-core particles. These columns are designed to tolerate repeated injections of minimally processed samples, while maintaining assay performance.
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In this study we review a successful next generation reversed solid-phase extraction (SPE) product that produces cleaner extracts with simpler protocols and faster processing time.
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In this study we review reversed-phase (RP) column selection considerations for peptide mapping applied to the routine characterization and analysis of biotherapeutic proteins.
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The main goal of this study is to investigate the long-term batch-to-batch reproducibility of 10 different lots of XBridge BEH C18 Columns. Discover the findings of this study.
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Having reproducible columns is critical for the success of batch to batch testing of stationary phases, as well as ensuring lifelong performance for the assay.
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We demonstrate how to increase productivity in the lab and mitigate risk through increased reproducibility, recovery, and robustness of assays performed in the development and manufacturing of biopharmaceutical drug products.
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Successfully replicates methods, producing equivalent chromatographic separation and analytical results generated by the method to the results obtained on the comparable LC systems.
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In this study demonstrates how the HSS T3 stationary phase is a reliable stationary phase, as three batches made over a five-year span provide comparable results.
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It is essential for the analytical laboratories to successfully transfer analytical methods. We present a transfer of the HPLC method for related substances analysis of metoclopramide HCl.
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Eurofins Bio-Pharma Product Testing applied a modern, risk-based approach to method migration and was able to understand the impact of introducing state-of-the-art technology for their legacy methods.
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Although development and quality control labs might be slow to replace existing technologies, modernization can benefit legacy methods and future development activities.
CONTACT INFORMATION
VIDEOS
BROCHURES AND DATASHEETS
- A HPLC System For An Efficient And Productive QC Lab
- A HPLC System For A New Era Of Intuitive Simplicity
- Arc HPLC
- Mass Detection For Undergraduates
- Compliance And Validation Services For Waters Informatics Solutions
- Control Your Bioprocess Development: Faster Decisions With Quality Data
- Adopting Enabling Informatics Technologies To Drive Digital Transformation And Data Integrity
- Metrology Teams Collaborating With Waters
- How Are You Addressing Site Expansions While Meeting Important Project Deadlines?
- Increase Employee Retention And Compliance By Investing In Quality Training From Waters
- Generate Revenue And Attract New Projects While Conserving Capital
- Four Keys To Great Bioanalytical Methods
- MaxPeak Premier Columns For Peptide Analysis
- Eliminate Doubt With Chemistry Technical Services
- MaxPeak Premier For Glycan Analysis
- LC And LC-MS Chemistry Consumables For Bioseparations
- MaxPeak Premier Columns For Intact And Subunit Protein Analysis
- MaxPeak Premier Columns For Protein SEC Analysis
- Solutions For Aggregate And Fragment Analyses
- Is NSA Sabotaging Your Lab's Productivity
- Waters Liquid Chromatography And LC-MS Solutions
- ACQUITY Premier Analytical Solution
- Comprehensive Support For Regulated Laboratories With FlexCHOICE Service Coverage
- Protect Your Lab Instruments From Expected Downtime With FlexCHOICE Service Coverage
- Upgrade Your LC And LC-MS Systems With The FlexUP Technology Renewal Program