Join us to celebrate 20 years of UPLC innovation. Discover how Waters' groundbreaking technology revolutionized chromatography separations, enhancing speed, sensitivity, and resolution.

See how the Alliance iS HPLC System console mirrors the information provided by the touchscreen app and allows the user to efficiently execute multiple tasks at once, saving valuable time.

Here, we showcase how the Alliance iS HPLC System saves users time by streamlining operations and enabling users to effortlessly execute numerous tasks at the same time.

Explore the features of a HPLC system that elevates your quality control lab, minimizes system downtime, and improves lab productivity.

Quality Control labs face stringent, ever-evolving compliance and data quality requirements. Discover a system that can help labs meet increasingly tight deadlines with confidence.

Discover how an innovative technology enhances LC-MS analysis of GLP-1 receptor agonists by minimizing peptide loss and improving assay sensitivity and consistency.

Explore a novel HPLC-UV/MS method for analyzing GLP-1 analogs to address critical challenges in peptide separation, impurity detection, and performance for improved reproducibility.

Liquid chromatography revolutionizes science with precision. Discover a technology that leads the charge in enhancing HPLC performance for breakthroughs in health, safety, and environmental research.

By embracing data-driven insights, companies can confidently navigate complexities, reduce risks, and deliver trusted products to global markets.

Gain expert insights into the driving forces behind change management, the associated obstacles within a QC lab, and best practices for guiding change when implementing new technology or procedures.

Here, the USP Tryptophan monograph is evaluated using two HPLC systems. Stability, sensitivity, and performance improvements are assessed with a diffusion-bonded mixer versus standard configurations.

Learn about the challenges in HPLC separations of metal-sensitive analytes and how one innovative solution provides improved separations of analytes that adsorb on metal services.

Understand the ease and added compliance provided in using embedded software tools in the replication or transfer of an existing method to a new HPLC system.

What does two decades of impact look like? Read on to learn about the UPLC system that has redefined industry standards for runtime, resolution, peak shape, and peak capacity.

Successful method migration to a new HPLC system can be challenging. The gradient USP method for Quetiapine Fumarate Impurities was analyzed on two legacy HPLC systems and on modern technology.

The USP monograph of atorvastatin requires adherence to strict criteria for the assay analysis of atorvastatin. In this study, several strategies were implemented to meet the stipulated USP monograph criteria.

The system suitability solution sample from the cetirizine hydrochloride organic impurities USP monograph was used to assess the impact of the needle wash and needle wash design on HILIC separations.

The USP monograph for Azithromycin Organic Impurities was chosen as a representative method. Explore the challenges of this method, and compare the results obtained across a number of different HPLC systems.

The rising popularity of vitamin supplements necessitates ensuring product content accuracy. In this study, we demonstrate the ability to achieve the same quantitative results on legacy and newer HPLC systems.

Soft drinks often contain one or more additives, such as benzoate or sorbate, and/or acesulfame K, saccharin, or aspartame. In this study, a HPLC System was employed for the analysis of these additives.

This study demonstrates the successful scaling and migration of a hydrophilic interaction liquid chromatography method for ribavirin analysis from a sub-2 µm column to larger particle sizes on different HPLC systems.

The ability to migrate methods across HPLC systems is essential as systems are updated. Review a normal phase method that provides a means for quantification of tocopherols in vitamin supplements.

In many regulated labs, there is a need for reliable, robust HPLC systems capable of operating for extended periods of time to accommodate the demand for high instrument utilization and product timelines.

This study established a robust HPLC method for analyzing the major active compounds in ashwagandha. Explore the impact of an optimized extraction method using ultrasound and ethanol/methanol/water solvent mixture.

In this study, the injection precision of an Alliance iS HPLC System was evaluated using four compendial HPLC methods from the USP with challenging method conditions and strict system suitability criteria.

See how you can achieve seamless method transfer from systems equipped with quaternary or binary solvent managers, maintaining separation selectivity without time-consuming method re-optimization.

Explore results from a study assessing the ability of a modern HPLC system to support manufacturing labs with the routine downstream analysis of DNA/mRNA therapeutics using SEC.

This study assesses a modern HPLC system within a routine QC testing environment focused on peptide-size biopharmaceuticals.

Here, a next-generation HPLC system tailored for the robust analysis of biopharmaceutical applications is evaluated for its advantages in size exclusion chromatography (SEC) separations.

Gain insight into a global interlaboratory method transfer of a USP organic impurities method that was successfully conducted across eight sites using an advanced HPLC System.

Explore a collection of use cases demonstrating the performance of an intuitively simple HPLC system, including common pharmaceutical QC applications, method migration from legacy systems, and more.

Explore the advantages of a bio-inert HPLC system through the migration and modernization of a compendial SEC method outlined in the United States Pharmacopeia (USP) General Chapter <129>.

Explore findings from a study evaluating the performance of a modern HPLC system in comparison to a legacy system in a routine QC testing environment for biopharmaceuticals.

Learn in detail about the impact of change management on the pharmaceutical industry and how it ensures innovations and improvements are managed effectively.

We demonstrate how surface chemistry technology enhances the analysis of intact proteins, peptides, nucleotides, glycans, and cell cultures, addressing evolving biopharmaceutical therapeutic needs.

Learn about the hardware changes that allow for scaling and modernization of chromatographic methods and how mismatching particle size and liquid chromatographic systems can result in poor performance.

Explore the latest updates to the USP <621> guidelines that involve changes to the allowable modifications to gradient methods and updates to system suitability parameters.

Learn how Empower Software addresses modifications to certain calculations and maintains relevant naming conventions and calculations to help customers update SOPs to prevent disruption to operations.

Are you looking to update a validated liquid chromatography method? This guide offers a step-by-step approach to adjusting your methods that can help you achieve your goals and save time in the process.

Discover how analytical instrumentation, chemistries, and purpose-built informatics from Waters Corporation can help you eliminate the issues associated with older technology and outdated manual processes.

Here, we examine the cause and impact of common errors in Quality Control (QC) labs, the strategy for reducing those errors with an intuitive chromatography system, and more.

Explore results from an experiment analyzing the USP monograph for cetirizine hydrochloride assay and organic impurities on two legacy HPLC systems and migrating them to the Alliance™ iS HPLC System.

Gain insight into how the Quality Control team at Almac Sciences developed processes and strategies to help ensure a high quality of safe and effective products while also maximizing efficiency.

A partnership facilitated capacity, efficiency, and compliance of pharmaceutical manufacturing and analytical service increases for a prominent CDMO.

Discover a single HPLC method that can replace several separate methods for the analysis of the assays and organic impurities of APIs naphazoline hydrochloride and pheniramine maleate.

Carryover performance was assessed across HPLC systems using a scaled method based on the USP monograph for chlorhexidine hydrochloride organic impurities. Explore results and mitigation strategies.

An isocratic USP monograph for ibuprofen and related organic impurities was used to assess a method migration between HPLC systems. Explore results that demonstrate the ability to migrate methods.

Learn how the gradient method allowances described in USP General Chapter <621> Chromatography, combined with a HPLC system, were employed for the USP monograph separation of abacavir sulfate.

Explore three perspectives on the capabilities and adoption of MAM workflows within the biopharmaceutical industry in addition to MAM resources for process and product control of biotherapeutic proteins.

Multi-Attribute Method analysis using liquid chromatography – mass spectrometry has emerged as a valuable tool for drug discovery, development, process monitoring and quality control.

With industry-leading scientific expertise and customer support, we have pioneered solutions to some of the most pressing challenges facing customers interested in adopting MAM into their organizations.

Explore the utility of electron capture dissociation (ECD) on the SELECT SERIES Cyclic IMS instrument for unambiguous assignment of glycosylation site locations for 11 Oglycopeptide species of ENBREL.

Learn about a premier system offering a flexible LC platform that can be broadly deployed across labs to support the analytical needs in the development and manufacturing of biotherapeutics.

This notebook from the Biopharmaceutical Scientific Operations Team at Waters illustrates key attribute monitoring workflows to improve and streamline MAM analysis of biotherapeutic proteins.

Employing the Multi-Attribute Method based on liquid chromatography-mass spectrometry analysis represents a critical advancement in evaluating the complexity of biotherapeutic molecules.