Improving Chromatographic Separations Of Biopharmaceuticals With MaxPeak High Performance Surfaces (HPS) Technology

Within the pharmaceutical space, biopharmaceutical therapeutics have consistently been the fastest-growing segment, necessitating analytical testing advances for more efficient discovery, development, and manufacturing to meet the needs of patients. In this new era of innovative medicine driven by these complex molecules, scientists utilizing legacy instrumentation are increasingly facing challenges related to these therapeutics. These challenges often stem from the non-specific adsorption of analytes containing electron-rich functional groups onto stainless-steel components typically found in legacy instruments. In practice, non-specific adsorption manifests as poor reproducibility, broad peak shapes, and reduced sensitivity and may call into question the accuracy of results. Given the growing analytical complexity in the biopharmaceutical space, a holistic solution is needed to overcome these challenges. Waters has pioneered a first-of-its-kind surface chemistry technology, MaxPeak™ High Performance Surfaces (HPS) to address these concerns.

Within this biopharmaceutical eBook is a compilation of application notes demonstrating how the implementation of MaxPeak HPS Technology increased performance and efficiency in the analysis of intact proteins, peptides, nucleotides, glycans, and cell culture. Meet the evolving needs of biopharmaceutical therapeutics with a universal platform for liquid chromatography.