Low Adsorption UPLC Systems And Columns Based On MaxPeak High Performance Surfaces: The ACQUITY Premier Solution

Here, we examine the complexities of high-performance liquid chromatography (HPLC) when dealing with metal-sensitive analytes, particularly those with electron-rich functional groups. Traditional stainless steel components often lead to poor peak shapes and analyte loss due to adsorption and corrosion, particularly in acidic conditions. To address these challenges, Waters Corporation introduced the ACQUITY Premier Solution, featuring MaxPeak™ High Performance Surfaces (HPS). This innovative technology minimizes metal surface interactions, enhancing the separation of sensitive compounds such as adenosine triphosphate (ATP) and oligonucleotides. The system not only demonstrates superior performance in reducing analyte adsorption but also improves reproducibility and sensitivity across various applications, including bioanalysis and proteomics. This advancement positions the ACQUITY Premier Solution as a leading choice for laboratories seeking enhanced analytical precision and efficiency.