Evaluating A Flexible LC Platform That Can Be Broadly Deployed In Biopharmaceutical Labs

By Jacob Kellett, Brooke M. Koshel, Hua Yang, Robert E. Birdsall, Stephan M. Koza, Ying Qing Yu

Increasing demands on analytical labs across industry requires LC platforms to be utilized in an efficient manner to increase productivity. In this study, we evaluate the compatibility of the Waters ACQUITY Premier System with a broad set of LC techniques to determine its applicability as an LC platform that can be broadly deployed to support biopharmaceutical labs. Specifically, ion-exchange, size-exclusion, and hydrophobic interaction chromatography techniques are evaluated as complementary techniques to those already established to exhibit performance gains with MaxPeak High Performance Surfaces (HPS) Technology. This study demonstrates that the ACQUITY Premier System is compatible with methods that incorporate high-ionic strength mobile phases and can reliably run established methods with a high degree of comparability facilitating easier method transfer between LC platforms.

Learn more about how the Waters ACQUITY Premier System with MaxPeak HPS Technology offers a flexible LC platform that can be broadly deployed across labs to support the analytical needs in the development and manufacturing of biotherapeutics.