Bio-Printed 3D Liver Model And High-Content Imaging For Assessment Of Compound Toxicity Effects

By Prathyushakrishna Macha, Oksana Sirenko, Molecular Devices, and Sarah M. Moss, James B. Hoying, Advanced Solutions Life Sciences

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Three-dimensional (3D) cellular models significantly enhance the accuracy of non-clinical drug safety predictions. The advent of 3D bioprinting technology has revolutionized the creation of intricate models to offer precise spatial control and a diverse array of matrices that facilitate the development of complex tissue structures. In this application note, we present a novel method for the automated generation of 3D cellular liver models utilizing a multi-tool robotic device equipped with liquid handling capabilities. This automated process not only streamlines the creation of 3D cellular models but also enhances the reproducibility and reliability of toxicity testing to pave the way for more accurate and efficient drug safety evaluations.

Access the full application note to learn more.