Characterization Of Drug Binding Activity And Biopharmaceutical Stability

Rapid and accurate characterization of biopharmaceuticals is essential for the early selection of therapeutic candidates. In this webinar, we focus on enthalpy screening, a new and recently published ITC technique that is showing promise for quickly and precisely characterizing the binding enthalpy of new drugs or biotherapeutics. This rapid screening technique, coupled with the fully automated Affinity ITC instrument, shortens the time required to produce the powerful thermodynamic signature for any biotherapeutic being considered for further development.

Isothermal Microcalorimetry is another critical biologic formulation analytical technique for understanding complex, high concentration formulation stability of active biopharmaceuticals. The flexible and powerful TAM IV instrument provides the high level of sensitivity required for this technique, which promises to dramatically shorten the time it takes to determine the accurate shelf-life kinetics and aggregation kinetics for protein formulations, and even new high concentration biotherapeutic formulations.