
ABOUT TA INSTRUMENTS
TA Instruments (a division of Waters Corporation) is the world leader in manufacturing industry-leading systems for thermal analysis, rheology, microcalorimetry, and mechanical analysis. We offer innovative and reliable instruments that help scientists in top laboratories test the physical properties of their materials. Our instruments contribute to leading discoveries in materials science, medicine, medical devices, and other areas of science devoted to improving our world. With direct operations in 24 countries, we are uniquely positioned to support all our customers with an extensive local support network. We are committed to providing high reliability and high-performance products to meet the needs of our customers.
FEATURED CONTENT
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Here, we review applications of Nano DSC and ITC for studying the stability of virus particles and their binding to cells, as well as for the identification of viruses.
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Explore the performance of an instrument with data analysis software capabilities that easily deconvolutes thermograms, enables differentiation between individual and interacting domains, and reports accurate Tm values.
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Carboxymethyl cellulose powder is a hygroscopic material used in a variety of applications. Here, the impact of moisture content on cohesion strength is measured using a shear cell accessory.
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Powder rheology is a useful tool for formulating and optimizing pharmaceutical tablet processing conditions. Investigate the influence of moisture content and substrate material on carboxymethyl cellulose powder wall friction.
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Learn how a DSC thermogram was able to detect and quantify the differences in varying drug loads with respect to thermal parameters including Tm, Tonset, and enthalpy (ΔH).
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Isothermal titration calorimetry (ITC) is a technique where heat is measured under constant pressure. Explore advances that will enable investigators to expand their research using ITC.
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Powder flow measurements are increasingly important in pre-formulation and formulation stages. Analyze the processing behavior of two lactose excipients through multiple powder rheology measurements of milled and spray-dried lactose.
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Explore results from a comparability study that utilized a nano differential scanning calorimeter to detect biomolecular structure changes in response to subtle manipulations of a liquid protein reference formulation.
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Isothermal titration calorimetry is a powerful analytical tool to study molecular binding. Learn about the development of a representative binding assay that measures Ca2+ interactions with a calcium ionophore.
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Enthalpy screen, incremental titration, and continuous titration were utilized to characterize the binding of Furosemide and Carbonic Anhydrase II. See how these ITC methods compare in the experiment results.
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Learn how the accuracy (melting temperature and heat of fusion) and utility of Differential Scanning Calorimetry data is greatly diminished for materials that undergo Apparent Melting and much more.
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Explore a systematic thermal analysis approach for detecting drug-excipient incompatibility. The proposed method uses the approach of apparent melting and provides a rapid screening protocol.
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Gain a better understanding of the most commonly used microcalorimetric techniques within pharmaceutical science, including stability and compatibility tests, determination of small amounts of amorphic content, and characterizing polymorphism.
CONTACT INFORMATION
TA Instruments
159 Lukens Dr,
New Castle, DE 19720
UNITED STATES
Phone: 302-427-4000
Contact: Customer Service and Support
FEATURED PRODUCTS AND SERVICES
BROCHURES
E-BOOKS
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See how today’s leading instrumentation helps researchers get crucial information more rapidly so they can get to clinical trials faster with more reliable products.
WEBINARS
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Here, we focus on how the apparent melting approach can provide a rapid screening protocol for detection and analysis of drug-excipient incompatibility in mixtures and formulas.
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Here, we compare theory and results for thermodynamic and apparent melting and explain why it is important to distinguish between them when interpreting results from DSC.
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We dive into DSC testing and analysis of pharmaceutical materials to better understand how to obtain accurate results and avoid potential problems with data interpretation.
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Here, we will explore how to quantify the glass transition temperature of an amorphous pharmaceutical solid through the use of Differential Scanning Calorimetry (DSC) and Modulated DSC.
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Here, we explore enthalpy screening, a new and recently published ITC technique that is showing promise for rapidly and accurately characterizing the binding enthalpy of new drugs or biotherapeutics.
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Dr. Shawn Owen discusses advanced characterization techniques to assess antibody-drug conjugates (ADCs) and antibody-fusion proteins.
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Differential Scanning Calorimetry (DSC) is typically used during biopharmaceutical development to characterize a biomolecule. Here, we demonstrate the suitability of DSC for studies of opaque solutions and slurries.