FEATURED CONTENT

• Analysis Of Drug-Excipient Incompatibility In Discovery And Formulation Development

  We analyze drug-excipient incompatibility using a microcalorimeter system equipped with a multi-sample cell capable of simultaneously measuring highly sensitive heat flow data from up to three samples.

• Characterizing Virus Structure And Binding

  Here, we review applications of Nano DSC and ITC for studying the stability of virus particles and their binding to cells, as well as for the identification of viruses.

• Determining Thermal Stability Of Antibodies With A Nano DSC

  Explore the performance of an instrument with data analysis software capabilities that easily deconvolutes thermograms, enables differentiation between individual and interacting domains, and reports accurate Tm values.

• Effect Of Moisture On Cohesion Strength Of Carboxymethyl Cellulose Powder

  Carboxymethyl cellulose powder is a hygroscopic material used in a variety of applications. Here, the impact of moisture content on cohesion strength is measured using a shear cell accessory.

• Effect Of Moisture And Substrate Material On Wall Friction Angle Of Powder

  Powder rheology is a useful tool for formulating and optimizing pharmaceutical tablet processing conditions. Investigate the influence of moisture content and substrate material on carboxymethyl cellulose powder wall friction.

• Characterization Of Biopharmaceutical Stability

  Learn how a DSC thermogram was able to detect and quantify the differences in varying drug loads with respect to thermal parameters including Tm, Tonset, and enthalpy (ΔH).

• Advances In Native Binding Assays

  Isothermal titration calorimetry (ITC) is a technique where heat is measured under constant pressure. Explore advances that will enable investigators to expand their research using ITC.

• The Impact Of Powder Morphology On Pharmaceutical Excipient Performance

  Gain insight into the processing behavior of two lactose excipients through multiple powder rheology measurements of milled and spray-dried lactose.

• A Novel Thermodynamic Assay For Biomolecular Structure Stability

  This comparability study utilized a nano differential scanning calorimeter to detect biomolecular structure changes in response to subtle manipulations of liquid protein reference formulation.

• Isothermal Titration Calorimetry In Organic Solvent Systems

  Isothermal titration calorimetry is a powerful analytical tool to study molecular binding. Learn about the development of a representative binding assay that measures Ca2+ interactions with a calcium ionophore.

• Workflow Solutions: Choosing The Right ITC Binding Experiment

  Enthalpy screen, incremental titration, and continuous titration were utilized to characterize the binding of Furosemide and Carbonic Anhydrase II. See how these ITC methods compare in the experiment results.

• A New Approach To Characterizing Crystalline Structure

  Learn how the accuracy (melting temperature and heat of fusion) and utility of Differential Scanning Calorimetry data is greatly diminished for materials that undergo Apparent Melting and much more.

• A New Approach To Detecting Drug-Excipient Incompatibility

  Explore a systematic thermal analysis approach for detecting drug-excipient incompatibility. The proposed method uses the approach of apparent melting and provides a rapid screening protocol.

• Pharmaceutical Applications Of Isothermal Microcalorimetry

  Examine the most commonly used microcalorimetric techniques in pharma, including stability and compatibility tests, determination of small amounts of amorphic content, and characterizing polymorphism.