FEATURED CONTENT

• Characterizing Binding Interactions By ITC

  Isothermal Titration Calorimetry is a powerful technique for analyzing biochemical binding events, which is crucial for understanding molecular interactions and enzyme kinetics in biomedical research.

• Optimization Of The Freeze Drying Process Using Modulated Differential Scanning Calorimetry

  Freeze-drying stabilizes biologics but requires optimizing parameters like temperature and structure. Explore how modulated DSC™ improves precision in analyzing transitions.

• Rheological Properties Of Pharmaceutical Excipients: Lactose Monohydrate And Carboxymethyl Cellulose

  Explore lactose monohydrate and CMC rheology, highlighting their flow, cohesion, and compressibility properties to optimize pharmaceutical formulations under varying stress and temperature conditions.

• Characterizing The Effects Of Moisture On Pharmaceutical Materials

  Moisture impacts pharmaceutical ingredients’ stability and efficacy, causing phase changes and hydrate formation. Discovery SA enables humidity and temperature profiling for improved drug formulation.

• Characterization Of Pharmaceutical Materials With Modulated DSC

  Modulated DSC addresses challenges in pharmaceutical material characterization, enabling precise analysis of glass transitions, and overlapping transitions, enhancing insights beyond standard DSC.

• Detection And Quantification Of Amorphous Content In Materials

  Complementary analytical techniques like DSC, MDSC, cRHp, DVS, and SolCal accurately quantify amorphous content in pharmaceuticals to ensure stability, compatibility, and efficiency.

• Thermal Analysis In The Pharmaceutical Industry

  Thermal analysis techniques provide valuable insights into pharmaceutical material properties, ensuring compatibility, stability, and quality control in drug development and production processes.

• Quantitative Determination Of Amorphous And Crystalline Drug In Polymer Microspheres

  Biodegradable polymer microspheres control drug release through crystalline and amorphous properties, analyzed using DSC, MDSC, and TGA to determine composition and stability for precise delivery.

• An Alternative Method Of Drug-Excipient Characterization

  Isothermal microcalorimetry (IMC) rapidly screens API-excipient compatibility, detecting physical and chemical interactions faster than conventional methods, saving time and effort in pharmaceutical formulation development.

• Rapid Thermal Stability Screening And Selection Of Monoclonal Antibody Drug Products

  Learn more about a differential scanning calorimeter that offers thermal stability screening of buffer formulations and protein sequence modifications.

• Leveraging Innovative Analytics To Ensure The Thermal Stability Of mAb Drug Products

  Uncover how innovative Rapid Screening-Differential Scanning Calorimeter technology is enabling robust analysis and regulatory compliance by ensuring the thermal stability of antibody drug products.

• Rapid Thermal Stability Screening Of High Concentration Biologic Drugs

  Explore data demonstrating the effectiveness of a rapid screening-differential scanning calorimeter as well as its detection limits and the range of concentrations suitable for DSC analysis.

• Analysis Of Drug-Excipient Incompatibility In Discovery And Formulation Development

  We analyze drug-excipient incompatibility using a microcalorimeter system equipped with a multi-sample cell capable of simultaneously measuring highly sensitive heat flow data from up to three samples.

• Characterizing Virus Structure And Binding

  Here, we review applications of Nano DSC and ITC for studying the stability of virus particles and their binding to cells, as well as for the identification of viruses.

• Determining Thermal Stability Of Antibodies With A Nano DSC

  Explore the performance of an instrument with data analysis software capabilities that easily deconvolutes thermograms, enables differentiation between individual and interacting domains, and reports accurate Tm values.

• Effect Of Moisture On Cohesion Strength Of Carboxymethyl Cellulose Powder

  Carboxymethyl cellulose powder is a hygroscopic material used in a variety of applications. Here, the impact of moisture content on cohesion strength is measured using a shear cell accessory.

• Effect Of Moisture And Substrate Material On Wall Friction Angle Of Powder

  Powder rheology is a useful tool for formulating and optimizing tablet processing conditions. Investigate the influence of moisture content and substrate material on carboxymethyl cellulose powder wall friction.

• Characterization Of Biopharmaceutical Stability

  Learn how a DSC thermogram was able to detect and quantify the differences in varying drug loads with respect to thermal parameters including Tm, Tonset, and enthalpy (ΔH).

• Advances In Native Binding Assays

  Isothermal titration calorimetry (ITC) is a technique where heat is measured under constant pressure. Explore advances that will enable investigators to expand their research using ITC.

• The Impact Of Powder Morphology On Pharmaceutical Excipient Performance

  Gain insight into the processing behavior of two lactose excipients through multiple powder rheology measurements of milled and spray-dried lactose.