Measuring Thermodynamic Parameters In The Drug Development Process

While the measurement of thermodynamic properties has become routine, the information they provide is often complex and not fully understood. Interpreting these properties can be challenging due to the numerous atomic-level changes that occur when transitioning from the free to the bound state of a protein-ligand complex. In this webinar, Dr. Ladbury investigates what thermodynamic parameterization can reveal through a limited set of example protein-ligand interactions. He poses the critical question: Can these measurements truly enhance our understanding of biological processes and inform decisions in pharmaceutical development? By examining specific cases, Dr. Ladbury highlights how thermodynamic data can offer insights into the stability and dynamics of protein-ligand interactions.

Discover how these insights are crucial for optimizing drug efficacy and safety to aid in the design of better therapeutic agents.