DSC Characterization Of Crystalline Structure In Pharmaceuticals: Apparent Melting

This webinar on “Apparent Melting” is part two of a three-part series on the use of differential scanning calorimetry (DSC) to characterize crystalline structure of foods and pharmaceuticals. Although apparent melting looks like true/thermodynamic melting and causes a loss of crystalline structure, it creates significant limitations for analysis and reporting of typical properties such as melting point and heat of fusion. In addition, apparent melting always causes chemical change which affects measurement of other important properties such as purity, identification of polymorphs, and even glass transitions of melted materials. Here, we will compare both theory and results for thermodynamic and apparent melting and explain why it is important to distinguish between them when interpreting results from DSC.