Effect Of Moisture And Substrate Material On Wall Friction Angle Of Carboxymethyl Cellulose Powder

By Jennifer Vail PhD, Kimberly Dennis PhD, and Tianhong (Terri) Chen PhD

Powder rheology is a useful tool for formulating and optimizing processing conditions of pharmaceutical tablets. The angle of wall friction can be used to gage the adhesion present between a powder and tablet punch material, with higher angles correlating to higher wall friction and adhesion. This adhesion may lead to tablet sticking and wall friction measurements can be used to understand how formulation or environmental conditions may impact sticking. This work investigates the influence of moisture content and substrate material on the wall friction of carboxymethyl cellulose powder, which is used as an excipient in tablet formulations.