Rapid Thermal Stability Screening And Selection Of Monoclonal Antibody Drug Products

Short-term thermal stability testing is essential for maintaining product quality and securing regulatory approval for antibody drug products. The TA Instruments™ RS-DSC (Rapid Screening-Differential Scanning Calorimeter) facilitates the thermal stability analysis of buffer formulations and protein sequence alterations. This instrument enables the simultaneous screening of up to 24 samples at concentrations matching their formulation strength. This device can be used for efficient short-term thermal stability testing of buffers and the evaluation of protein modifications in the development of antibody drug products.

A clear understanding of the structure-function relationship of antibodies is crucial for identifying how functional changes arise, whether due to modifications in solution conditions or protein sequence. Characterizing the structure of antibodies plays a key role in uncovering these variations. Moreover, evaluating the stability of biomolecules under different thermal conditions is vital for ensuring both the quality and regulatory approval of these therapeutic products.

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