Application Note

Chromatography System Column, Qualification And Protein Purification Demonstration

Chromatography Lab GettyImages-482759508

Analyze a demonstration of the DynaChrom™ Single Use Chromatography System's functionality while performing standard processing operations such as column qualification and purification of an IgG1 mAb using the platform TruChrom™ automation recipes for column qualification and bind-and-elute purification.

The DynaChrom™ Single-use Chromatography System, is designed to accommodate a wide range of downstream processing needs through features like:

  • Modular, single-use fluid transfer assemblies (FTAs) at ¼”, ⅜”, ½” and ¾” inner diameters (ID) assembled with the Thermo Scientific™ BioTitan™ Retention Devices to enhance reliability and integrity at high pressure operations
  • Novel single-use diaphragm valve design with innovative ring flush to completely and cleanly transition solutions between phases
  • Up to three high-performance, low-pulsation pumps capable of covering a wide flow range and enabling binary and tertiary gradients in both discrete (step) and continuous (linear) formats
  • Internalized column upflow/downflow valving control
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