Comprehensive Charge Variant Analysis Made Simple With Intabio ZT System

Cut out risk, cut out information gaps. Gain multiple pieces of critical data up front.

Accelerate candidate selection by achieving separation, quantitation, and direct identification of biopharmaceutical charge variants and their proteoforms with icIEF-UV/MS via the Intabio ZT system.

Access multidimensional data in minutes instead of weeks

The Intabio ZT system couples icIEF separation and UV detection with high resolution mass spectrometry on the ZenoTOF 7600 system. Experience one integrated workflow with a single, accessible dataset containing the required information to make the right decisions, fast.

Comprehensive proteoform identification in minutes

The process of identifying individual charge variant components and interpreting their structural differences conventionally takes weeks and requires the use of multiple instruments, with multiple manual steps.

With the Intabio ZT system - separation, quantitation and identification of individual charge variants can be achieved in minutes on a single platform

Leverage key analytical functions with microfluidic chip-based technology

The Intabio ZT cartridge enables key analytical functions using proprietary microfluidic chip-based integrated icIEF-UV/MS technology.

• Separation of charge variants with imaged capillary isoelectric focusing (icIEF)

• Quantitation with real-time UV detection

• Electrospray ionization for further mass spectrometry identification

Eliminate the guess work with the ZenoTOF 7600 system

Enable a more detailed characterization approach by leveraging the enhanced capabilities of the powerful ZenoTOF 7600 system with EAD fragmentation technology.

Guide decisions with multidimensional analysis using the Intabio ZT system

Let Biologics Explorer software do the heavy lifting

Maintain data continuity with a single workflow producing one, accessible dataset, where UV peaks correlate with MS peaks. Let Biologics Explorer software do the heavy lifting with pre-built workflows for charge variant analysis. Get the required information to make confident decisions, fast.

Separate, characterize, identify

High-throughput characterization with rapid multi-attribute monitoring of intact biotherapeutics and identification of charge variants throughout the drug development pipeline.

• Acquire charge variant separation profiles in minutes

• Achieve highly confident critical quality attribute identification

• Identify proteoforms that could impact product quality

Wherever you play in the pipeline, change the game in modern medicine

• Clone selection, cell line development

  Intact protein analysis, charge variant analysis, PTM characterization

• Process development

  Charge variants, glycoforms, PQA assessment

• Formulation

  Stability/degradation

• Manufacturing attribute monitoring

  CQA and PQA monitoring