Application Note

Comprehensive Mapping Of Disulfide Linkages In Etanercept Using An EAD Based LCMS/MS Methodology

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Achieve superior sequence and disulfide linkage confirmation, especially for long disulfide peptides compared to traditional fragmentation mechanisms. This experiment, featuring the ZenoTOF 7600 system and Biologics Explorer, describes the comprehensive mapping of disulfide linkages in etanercept using the EAD approach.

EAD workflow for disulfide linkage characterization provides the following features:

  • Confident identification
  • Accurate localization
  • High-quality MS/MS data
  • Powerful data analysis software
  • Streamlined solution
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